Ventricular-arterial coupling in a rat model of reduced arterial compliance provoked by hypervitaminosis D and nicotine.

Details

Serval ID
serval:BIB_7ECF1DD75BAA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Ventricular-arterial coupling in a rat model of reduced arterial compliance provoked by hypervitaminosis D and nicotine.
Journal
American Journal of Physiology. Heart and Circulatory Physiology
Author(s)
Jegger D., da Silva R., Jeanrenaud X., Nasratullah M., Tevaearai H., von Segesser L.K., Segers P., Gaillard V., Atkinson J., Lartaud I., Stergiopulo N.
ISSN
0363-6135
Publication state
Published
Issued date
10/2006
Peer-reviewed
Oui
Volume
291
Number
4
Pages
H1942-1951
Language
english
Notes
Publication types: Journal Article
Abstract
The vitamin D(3) and nicotine (VDN) model is one of isolated systolic hypertension (ISH) in which arterial calcification raises arterial stiffness and vascular impedance. The effects of VDN treatment on arterial and cardiac hemodynamics have been investigated; however, a complete analysis of ventricular-arterial interaction is lacking. Wistar rats were treated with VDN (VDN group, n = 9), and a control group (n = 10) was included without the VDN. At week 8, invasive indexes of cardiac function were obtained using a conductance catheter. Simultaneously, aortic pressure and flow were measured to derive vascular impedance and characterize ventricular-vascular interaction. VDN caused significant increases in systolic (138 +/- 6 vs. 116 +/- 13 mmHg, P < 0.01) and pulse (42 +/- 10 vs. 26 +/- 4 mmHg, P < 0.01) pressures with respect to control. Total arterial compliance decreased (0.12 +/- 0.08 vs. 0.21 +/- 0.04 ml/mmHg in control, P < 0.05), and pulse wave velocity increased significantly (8.8 +/- 2.5 vs. 5.1 +/- 2.0 m/s in control, P < 0.05). The arterial elastance and end-systolic elastance rose significantly in the VDN group (P < 0.05). Wave reflection was augmented in the VDN group, as reflected by the increase in the wave reflection coefficient (0.63 +/- 0.06 vs. 0.52 +/- 0.05 in control, P < 0.05) and the amplitude of the reflected pressure wave (13.3 +/- 3.1 vs. 8.4 +/- 1.0 mmHg in control, P < 0.05). We studied ventricular-arterial coupling in a VDN-induced rat model of reduced arterial compliance. The VDN treatment led to development of ISH and provoked alterations in cardiac function, arterial impedance, arterial function, and ventricular-arterial interaction, which in many aspects are similar to effects of an aged and stiffened arterial tree.
Keywords
Animals, Cardiac Volume/drug effects, Cardiac Volume/physiology, Cholecalciferol/pharmacology, Compliance, Coronary Vessels/drug effects, Coronary Vessels/physiology, Dose-Response Relationship, Drug, Elasticity/drug effects, Ganglionic Stimulants/pharmacology, Heart Ventricles/drug effects, Hemodynamics/drug effects, Hemodynamics/physiology, Hypertension/physiopathology, Male, Models, Cardiovascular, Nicotine/pharmacology, Rats, Rats, Wistar, Vascular Resistance/drug effects, Vascular Resistance/physiology, Ventricular Function
Pubmed
Web of science
Create date
28/01/2008 11:00
Last modification date
20/08/2019 15:39
Usage data