Solubilization of immune precipitates by complement in the absence of properdin or factor D

Détails

ID Serval
serval:BIB_7EAC684C6B00
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Solubilization of immune precipitates by complement in the absence of properdin or factor D
Périodique
FEBS Letters
Auteur(s)
Spath  P. J., Pascual  M., Meyer-Hanni  L., Schaad  U. B., Schifferli  J. A.
ISSN
0014-5793
Statut éditorial
Publié
Date de publication
07/1988
Peer-reviewed
Oui
Volume
234
Numéro
1
Pages
131-4
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul 4
Résumé
Various experiments have demonstrated that immune precipitates (IPs) are not solubilized by complement in the absence of alternative pathway function. To determine whether the characteristics of the IPs were responsible for these observations, we studied the solubilization (Sol) of IPs formed by bovine serum albumin (BSA)-rabbit antiBSA and tetanus toxoid (TT)-human antiTT. Sera deficient in properdin solubilized a fraction of BSA-antiBSA precipitates, although only when the IPs were formed in antibody excess. The same sera solubilized TT-antiTT precipitates with some delay but almost as efficiently as normal serum. Factor D-depleted serum solubilized a fraction of TT-antiTT precipitates too, indicating that Sol may proceed through activation of the classical pathway only. Thus, the requirements for complement-mediated Sol depend on the characteristics of the IPs and do not necessarily include alternative pathway function.
Mots-clé
Antibodies/immunology *Antigen-Antibody Complex Complement Activating Enzymes/*physiology Complement Activation Complement C3/physiology Complement C3b/metabolism Complement Factor D/*physiology Erythrocytes/immunology Humans Properdin/*physiology Receptors, Complement/metabolism Receptors, Complement 3b Serum Albumin, Bovine/*immunology Solubility Tetanus Toxoid/*immunology
Pubmed
Web of science
Open Access
Oui
Création de la notice
29/01/2008 14:52
Dernière modification de la notice
20/08/2019 15:39
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