Inflammasome Activation in Response to Eukaryotic Pathogens

Détails

ID Serval
serval:BIB_7E8C3D67BD87
Type
Partie de livre
Collection
Publications
Titre
Inflammasome Activation in Response to Eukaryotic Pathogens
Titre du livre
The inflammasomes
Auteur(s)
Gross O., Thomas C.J., Layland L.E.
Editeur
Springer
Lieu d'édition
Basel
ISBN
978-3-0348-0147-8
Statut éditorial
Publié
Date de publication
2011
Editeur scientifique
Couillin I., Pétrilli V., Martinon F.
Pages
65-84
Langue
anglais
Résumé
Inflammasomes are multi-protein complexes that serve as platforms for caspase-1 activation and subsequent proteolytic maturation of interkeukin 1ß (IL-1ß) within innate immune cells. The Nlrp3 inflammasome is the most fully characterised. It is activated by various endogenous danger signals such as environmental irritants, signals of tissue damage and pathogens. The broad spectrum of activators is reflected at the physiological level in its implication in normal and dysregulated immune responses, including various autoinflammatory diseases and the defence agaisnt numerous pathogens. Here, we summarise the present data on the activation of the Nlrp3 inflammasome by eukaryotic pathogens. Recent genetic studies using mice deficient in inflammasome components demonstrate the involvement of the inflammasome in the outcome of infection with the fungus Candida albicans, the helminth Schistosoma mansoni, as well as the malarial parasite Plasmodium berghei. Altered immune responses were respectively linked to the ability of live fungi, schistosomal egg antigen (SEA) or malarial hemozoin to activate the inflammasome and induce secretion of mature IL-1ß. The initial findings suggest that inflammasome activation may serve as a common and potentially druggable pathway in the defence agaisnt eukaryotic pathogens
Création de la notice
11/11/2011 10:27
Dernière modification de la notice
03/03/2018 18:41
Données d'usage