Simultaneous fat-free isotropic 3D anatomical imaging and T<sub>2</sub> mapping of knee cartilage with lipid-insensitive binomial off-resonant RF excitation (LIBRE) pulses.
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State: Public
Version: Author's accepted manuscript
License: All rights reserved
Serval ID
serval:BIB_7E6D89A98068
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Simultaneous fat-free isotropic 3D anatomical imaging and T<sub>2</sub> mapping of knee cartilage with lipid-insensitive binomial off-resonant RF excitation (LIBRE) pulses.
Journal
Journal of magnetic resonance imaging
ISSN
1522-2586 (Electronic)
ISSN-L
1053-1807
Publication state
Published
Issued date
05/2019
Peer-reviewed
Oui
Volume
49
Number
5
Pages
1275-1284
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
Improved knee cartilage morphological delineation and T <sub>2</sub> mapping precision necessitates isotropic 3D high-resolution and efficient fat suppression.
To develop and assess an isotropic 3D lipid-insensitive T <sub>2</sub> mapping technique of the knee for improved cartilage delineation and precise measurement of T <sub>2</sub> relaxation times.
Prospective.
Phantoms (n = 6) used in this study were designed to mimic the T <sub>1</sub> and T <sub>2</sub> relaxation times of cartilage and fat. The study cohort comprised healthy volunteers (n = 7) for morphometry and T <sub>2</sub> relaxation time measurements.
A high-resolution isotropic 3D T <sub>2</sub> mapping technique that uses sequential T <sub>2</sub> -prepared segmented gradient-recalled echo (Iso3DGRE) images and lipid-insensitive binomial off-resonant radiofrequency (RF) excitation (LIBRE) at 3T.
Numerical simulations and phantom experiments were performed to optimize the LIBRE pulse. Phantom studies were carried out to test the accuracy of the technique against reference standard spin-echo (SE) T <sub>2</sub> mapping. Subsequently, T <sub>2</sub> maps with and without LIBRE pulses were acquired in knees of healthy volunteers and the T <sub>2</sub> relaxation time values in different cartilage compartments were compared.
A two-tailed paired Student's t-test was used to compare the average T <sub>2</sub> values and the relative standard deviations (inverse measurement of the precision) obtained with and without LIBRE pulses.
A LIBRE pulse of 1 msec suppressed fat with an RF excitation frequency offset of 1560 Hz and optimal RF excitation angle of 35°. These results were corroborated by phantom and knee experiments. Robust and homogeneous fat suppression was obtained (a fat signal-to-noise ratio (SNR) decrease of 86.4 ± 2.4%). In phantoms, T <sub>2</sub> values were found in good agreement when comparing LIBRE-Iso3DGRE with SE (slope 0.93 ± 0.04, intercept 0.11 ± 1.6 msec, R <sup>2</sup> >0.99). In vivo, LIBRE excitation resulted in more precise T <sub>2</sub> estimation (23.7 ± 7.4%) than normal excitation (30.5 ± 9.9%, P < 0.0001).
Homogeneous LIBRE fat signal suppression was achieved with a total RF pulse duration of 1 msec, allowing for the removal of chemical shift artifacts and resulting in improved cartilage delineation and precise T <sub>2</sub> values.
2 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2019;49:1275-1284.
To develop and assess an isotropic 3D lipid-insensitive T <sub>2</sub> mapping technique of the knee for improved cartilage delineation and precise measurement of T <sub>2</sub> relaxation times.
Prospective.
Phantoms (n = 6) used in this study were designed to mimic the T <sub>1</sub> and T <sub>2</sub> relaxation times of cartilage and fat. The study cohort comprised healthy volunteers (n = 7) for morphometry and T <sub>2</sub> relaxation time measurements.
A high-resolution isotropic 3D T <sub>2</sub> mapping technique that uses sequential T <sub>2</sub> -prepared segmented gradient-recalled echo (Iso3DGRE) images and lipid-insensitive binomial off-resonant radiofrequency (RF) excitation (LIBRE) at 3T.
Numerical simulations and phantom experiments were performed to optimize the LIBRE pulse. Phantom studies were carried out to test the accuracy of the technique against reference standard spin-echo (SE) T <sub>2</sub> mapping. Subsequently, T <sub>2</sub> maps with and without LIBRE pulses were acquired in knees of healthy volunteers and the T <sub>2</sub> relaxation time values in different cartilage compartments were compared.
A two-tailed paired Student's t-test was used to compare the average T <sub>2</sub> values and the relative standard deviations (inverse measurement of the precision) obtained with and without LIBRE pulses.
A LIBRE pulse of 1 msec suppressed fat with an RF excitation frequency offset of 1560 Hz and optimal RF excitation angle of 35°. These results were corroborated by phantom and knee experiments. Robust and homogeneous fat suppression was obtained (a fat signal-to-noise ratio (SNR) decrease of 86.4 ± 2.4%). In phantoms, T <sub>2</sub> values were found in good agreement when comparing LIBRE-Iso3DGRE with SE (slope 0.93 ± 0.04, intercept 0.11 ± 1.6 msec, R <sup>2</sup> >0.99). In vivo, LIBRE excitation resulted in more precise T <sub>2</sub> estimation (23.7 ± 7.4%) than normal excitation (30.5 ± 9.9%, P < 0.0001).
Homogeneous LIBRE fat signal suppression was achieved with a total RF pulse duration of 1 msec, allowing for the removal of chemical shift artifacts and resulting in improved cartilage delineation and precise T <sub>2</sub> values.
2 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2019;49:1275-1284.
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Create date
29/10/2018 15:37
Last modification date
21/11/2022 8:20
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