The benefits of integration.

Détails

Ressource 1Télécharger: BIB_7E4EEA73958C.P001.pdf (1491.78 [Ko])
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_7E4EEA73958C
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
The benefits of integration.
Périodique
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
Auteur(s)
Ciuffi A.
ISSN
1469-0691 (Electronic)
ISSN-L
1198-743X
Statut éditorial
Publié
Date de publication
04/2016
Peer-reviewed
Oui
Volume
22
Numéro
4
Pages
324-332
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Retroviruses, including the human immunodeficiency virus (HIV), are notorious for two essential steps of their viral replication: reverse transcription and integration. This latter property is considered to be essential for productive replication and ensures the stable long-term insertion of the viral genome sequence in the host chromatin, thereby leading to the life-long association of the virus with the infected cell. Using HIV as a prototypic example, the present review aims to provide an overview of how and where integration occurs, as well as presenting general consequences for both the virus and the infected host.

Mots-clé
Host-Pathogen Interactions, Humans, Retroviridae/physiology, Virus Integration
Pubmed
Open Access
Oui
Création de la notice
10/05/2016 18:42
Dernière modification de la notice
08/05/2019 20:59
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