Genomics meets HIV-1

Détails

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Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_7E0CE8B166CA
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Genomics meets HIV-1
Périodique
Nature Reviews. Microbiology
Auteur(s)
Telenti  A., Goldstein  D. B.
ISSN
1740-1534 (Electronic)
Statut éditorial
Publié
Date de publication
11/2006
Peer-reviewed
Oui
Volume
4
Numéro
11
Pages
865-73
Langue
anglais
Notes
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't --- Old month value: Nov
Résumé
Genomics is now a core element in the effort to develop a vaccine against HIV-1. Thanks to unprecedented progress in high-throughput genotyping and sequencing, in knowledge about genetic variation in humans, and in evolutionary genomics, it is finally possible to systematically search the genome for common genetic variants that influence the human response to HIV-1. The identification of such variants would help to determine which aspects of the response to the virus are the most promising targets for intervention. However, a key obstacle to progress remains the scarcity of appropriate human cohorts available for genomic research.
Mots-clé
AIDS Vaccines/immunology Chromosome Mapping Chromosomes, Human *Genetic Predisposition to Disease *Genome, Human *Genomics HIV Infections/*genetics/*immunology/prevention & control/virology HIV-1/*immunology/*physiology Haplotypes Humans
Pubmed
Web of science
Création de la notice
25/01/2008 15:46
Dernière modification de la notice
03/03/2018 18:40
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