Sepsis syndrome: acquis et perspectives thérapeutiques [Sepsis syndrome: progress and therapeutic perspectives].

Details

Serval ID
serval:BIB_7DD334A12097
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Sepsis syndrome: acquis et perspectives thérapeutiques [Sepsis syndrome: progress and therapeutic perspectives].
Journal
Schweizerische Medizinische Wochenschrift
Author(s)
Schaller M.D.
ISSN
0036-7672 (Print)
ISSN-L
0036-7672
Publication state
Published
Issued date
1992
Volume
122
Number
20
Pages
768-775
Language
french
Notes
Publication types: English Abstract ; Journal Article ; Review
Abstract
To reduce the very high mortality rate due to septic shock, a new clinical entity has been defined: sepsis syndrome. The aggressive treatment of any sepsis syndrome should prevent the evolution towards a state of shock and thus reduce the risk of a fatal outcome. It consists in broad spectrum antibiotic therapy associated with hemodynamic support (volume resuscitation, vasopressors and inotropic agents) at the first signs of cardiocirculatory failure. Several pharmacological or immunological interventions--antagonists directed at mediators and multiple cytokines involved in the pathogenesis and perpetuation of sepsis syndrome and septic shock--have been successful experimentally. However, new therapies, such as those using monoclonal antibodies against endotoxins of TNF, cannot yet be considered established.
Keywords
Anti-Bacterial Agents, Antibodies, Monoclonal/therapeutic use, Antioxidants/therapeutic use, Cardiotonic Agents/therapeutic use, Combined Modality Therapy/methods, Cytokines/antagonists & inhibitors, Drug Therapy, Combination/therapeutic use, Fluid Therapy, Humans, Intensive Care/methods, Platelet Activating Factor/antagonists & inhibitors, Retrospective Studies, Shock, Septic/physiopathology, Shock, Septic/therapy
Pubmed
Create date
06/09/2011 18:54
Last modification date
20/08/2019 15:39
Usage data