Analysis of the dynamic co-expression network of heart regeneration in the zebrafish.

Détails

ID Serval
serval:BIB_7DD12795F918
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Analysis of the dynamic co-expression network of heart regeneration in the zebrafish.
Périodique
Scientific reports
Auteur(s)
Rodius S., Androsova G., Götz L., Liechti R., Crespo I., Merz S., Nazarov P.V., de Klein N., Jeanty C., González-Rosa J.M., Muller A., Bernardin F., Niclou S.P., Vallar L., Mercader N., Ibberson M., Xenarios I., Azuaje F.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Statut éditorial
Publié
Date de publication
31/05/2016
Peer-reviewed
Oui
Volume
6
Pages
26822
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Résumé
The zebrafish has the capacity to regenerate its heart after severe injury. While the function of a few genes during this process has been studied, we are far from fully understanding how genes interact to coordinate heart regeneration. To enable systematic insights into this phenomenon, we generated and integrated a dynamic co-expression network of heart regeneration in the zebrafish and linked systems-level properties to the underlying molecular events. Across multiple post-injury time points, the network displays topological attributes of biological relevance. We show that regeneration steps are mediated by modules of transcriptionally coordinated genes, and by genes acting as network hubs. We also established direct associations between hubs and validated drivers of heart regeneration with murine and human orthologs. The resulting models and interactive analysis tools are available at http://infused.vital-it.ch. Using a worked example, we demonstrate the usefulness of this unique open resource for hypothesis generation and in silico screening for genes involved in heart regeneration.
Mots-clé
Animals, Gene Expression, Heart/physiology, Heart Injuries/physiopathology, Myocardium/metabolism, Regeneration, Transcriptome, Zebrafish, Zebrafish Proteins/genetics
Pubmed
Web of science
Open Access
Oui
Création de la notice
14/06/2016 16:13
Dernière modification de la notice
20/08/2019 14:39
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