Toll-like receptors and RNA helicases: two parallel ways to trigger antiviral responses

Détails

ID Serval
serval:BIB_7DCF245040A0
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Toll-like receptors and RNA helicases: two parallel ways to trigger antiviral responses
Périodique
Molecular Cell
Auteur(s)
Meylan  E., Tschopp  J.
ISSN
1097-2765 (Print)
Statut éditorial
Publié
Date de publication
06/2006
Volume
22
Numéro
5
Pages
561-9
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Jun 9
Résumé
The early detection by the host of invading microorganisms, including viruses, depends on a limited number of specific receptors that recognize pathogen-associated molecular patterns (PAMPs). A few of these PAMPs, including ssRNA and dsRNA, are recognized by Toll-like receptors (TLR)-7/8 and TLR3, respectively. Activation of an antiviral TLR-dependent signaling cascade leads to the activation of the key transcription factors IRF and NF-kappaB, which promote antiviral responses through induction of specific genes. Recently, a second system has been described, which relies on the cytoplasmic recognition of dsRNA by RNA helicases such as RIG-I. In this review, we discuss the mechanistic aspects of these important arms of the host innate response to dsRNA and a few viral strategies utilized to counteract them.
Mots-clé
Animals Cytoplasm/metabolism DEAD-box RNA Helicases Humans *Immunity, Natural Models, Biological RNA Helicases/*metabolism RNA, Double-Stranded/metabolism RNA, Viral/*metabolism Signal Transduction Toll-Like Receptor 3/metabolism Toll-Like Receptors/*metabolism Virus Replication/physiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 16:19
Dernière modification de la notice
08/05/2019 20:58
Données d'usage