Clinical evaluation of iron treatment efficiency among non-anemic but iron-deficient female blood donors: a randomized controlled trial.

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Ressource 1Télécharger: BIB_7DAE5488CF11.P001.pdf (518.09 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_7DAE5488CF11
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Clinical evaluation of iron treatment efficiency among non-anemic but iron-deficient female blood donors: a randomized controlled trial.
Périodique
BMC Medicine
Auteur(s)
Waldvogel Sophie, Pedrazzini Baptiste, Vaucher Paul, Bize Raphael, Cornuz Jacques, Tissot Jean-Daniel, Favrat Bernard
ISSN
1741-7015 (Electronic)
ISSN-L
1741-7015
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
10
Numéro
1
Pages
8
Langue
anglais
Résumé
ABSTRACT: Iron deficiency without anemia (IDWA) is related to adverse symptoms that can be relieved by supplementation. Since a blood donation can induce such an iron deficiency, we investigated the clinical impact of an iron treatment after blood donation. METHODS: One week after donation, we randomly assigned 154 female donors with IDWA aged <50 years to a 4-week oral treatment of ferrous sulfate vs. placebo. The main outcome was the change in the level of fatigue before and after the intervention. Also evaluated were aerobic capacity, mood disorder, quality of life, compliance and adverse events. Biological markers were hemoglobin and ferritin. RESULTS: Treatment effect from baseline to 4 weeks for hemoglobin and ferritin were 5.2 g/L (p < 0.01) and 14.8 ng/mL (p < 0.01) respectively. No significant clinical effect was observed for fatigue (-0.15 points, 95% confidence interval -0.9 to 0.6, p = 0.697) or for other outcomes. Compliance and interruption for side effects was similar in both groups. Additionally, blood donation did not induce overt symptoms of fatigue in spite of the significant biological changes it produces. CONCLUSIONS: These data are valuable as they enable us to conclude that donors with IDWA after a blood donation would not clinically benefit from iron supplementation. Trial registration: NCT00689793.
Pubmed
Web of science
Open Access
Oui
Création de la notice
26/01/2012 13:52
Dernière modification de la notice
20/08/2019 14:38
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