The Drosophila TNF Eiger Is an Adipokine that Acts on Insulin-Producing Cells to Mediate Nutrient Response.

Détails

ID Serval
serval:BIB_7DAD4070486A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The Drosophila TNF Eiger Is an Adipokine that Acts on Insulin-Producing Cells to Mediate Nutrient Response.
Périodique
Cell metabolism
Auteur(s)
Agrawal N., Delanoue R., Mauri A., Basco D., Pasco M., Thorens B., Léopold P.
ISSN
1932-7420 (Electronic)
ISSN-L
1550-4131
Statut éditorial
Publié
Date de publication
12/04/2016
Volume
23
Numéro
4
Pages
675-684
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish

Résumé
Adaptation of organisms to ever-changing nutritional environments relies on sensor tissues and systemic signals. Identification of these signals would help understand the physiological crosstalk between organs contributing to growth and metabolic homeostasis. Here we show that Eiger, the Drosophila TNF-α, is a metabolic hormone that mediates nutrient response by remotely acting on insulin-producing cells (IPCs). In the condition of nutrient shortage, a metalloprotease of the TNF-α converting enzyme (TACE) family is active in fat body (adipose-like) cells, allowing the cleavage and release of adipose Eiger in the hemolymph. In the brain IPCs, Eiger activates its receptor Grindelwald, leading to JNK-dependent inhibition of insulin production. Therefore, we have identified a humoral connexion between the fat body and the brain insulin-producing cells relying on TNF-α that mediates adaptive response to nutrient deprivation.

Mots-clé
Adipokines/metabolism, Animals, Body Size, Cell Line, Drosophila Proteins/metabolism, Drosophila melanogaster/physiology, Food Deprivation, Insulin/metabolism, Insulin-Secreting Cells/metabolism, Mice, Tumor Necrosis Factor-alpha/metabolism
Pubmed
Open Access
Oui
Création de la notice
13/05/2016 9:16
Dernière modification de la notice
20/08/2019 15:38
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