D-serine increases adult hippocampal neurogenesis.

Détails

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Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_7D9F5BA1D887
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
D-serine increases adult hippocampal neurogenesis.
Périodique
Frontiers in Neuroscience
Auteur(s)
Sultan S., Gebara E.G., Moullec K., Toni N.
ISSN
1662-453X; 1662-4548 (Print)
ISSN-L
1662-453X
Statut éditorial
Publié
Date de publication
2013
Volume
7
Pages
155
Langue
anglais
Résumé
Adult hippocampal neurogenesis results in the continuous formation of new neurons and is a process of brain plasticity involved in learning and memory. The neurogenic niche regulates the stem cell proliferation and the differentiation and survival of new neurons and a major contributor to the neurogenic niche are astrocytes. Among the molecules secreted by astrocytes, D-serine is an important gliotransmitter and is a co-agonist of the glutamate, N-methyl-D-aspartate (NMDA) receptor. D-serine has been shown to enhance the proliferation of neural stem cells in vitro, but its effect on adult neurogenesis in vivo is unknown. Here, we tested the effect of exogenous administration of D-serine on adult neurogenesis in the mouse dentate gyrus. We found that 1 week of treatment with D-serine increased cell proliferation in vivo and in vitro and increased the density of neural stem cells and transit amplifying progenitors. Furthermore, D-serine increased the survival of newborn neurons. Together, these results indicate that D-serine treatment resulted in the improvement of several steps of adult neurogenesis in vivo.
Mots-clé
adult neurogenesis, astrocytes, d-serine, dentate gyrus, stem cell factor, stem cell niche
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/10/2013 13:17
Dernière modification de la notice
08/05/2019 20:57
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