Genetic aspects of normal and disturbed sleep.

Details

Serval ID
serval:BIB_7D8414C8EAEC
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Genetic aspects of normal and disturbed sleep.
Journal
Sleep Medicine
Author(s)
Tafti M.
ISSN
1878-5506 (Electronic)
ISSN-L
1389-9457
Publication state
Published
Issued date
2009
Volume
10 Suppl 1
Pages
S17-S21
Language
english
Abstract
Sleep disorders commonly involve genetic susceptibility, environmental effects, and interactions between these factors. The heritability of sleep patterns has been shown in studies of monozygotic twins, and sleep electroencephalogram patterns offer a unique genetic fingerprint which may assist in the identification of genes involved in the regulation of sleep. Genetic factors are also thought to play a role in sleep disorders; narcolepsy is a disabling sleep condition and research has revealed the complexity of underlying genetic and environmental influences in the development of this disorder. An understanding of sleep regulation at the molecular level is essential in the identification of new targets for the treatment of sleep disorders, and genome-wide association studies for both normal sleep and sleep disorders may shed new light on the molecular architecture of mechanisms regulating these behaviours.
Keywords
Cataplexy/genetics, Chromosome Mapping, Chromosomes, Human, Pair 21/genetics, Diseases in Twins/genetics, Electroencephalography, Genetic Predisposition to Disease/genetics, Haplotypes, Humans, Narcolepsy/genetics, Pedigree, Sleep/genetics, Sleep Disorders/genetics, Sleep Stages/genetics, Social Environment
Pubmed
Web of science
Create date
18/11/2009 12:32
Last modification date
20/08/2019 14:38
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