The Classification of Vitreous Seeds in Retinoblastoma and Response to Intravitreal Melphalan.

Détails

ID Serval
serval:BIB_7D49983C364C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The Classification of Vitreous Seeds in Retinoblastoma and Response to Intravitreal Melphalan.
Périodique
Ophthalmology
Auteur(s)
Francis J.H., Abramson D.H., Gaillard M.C., Marr B.P., Beck-Popovic M., Munier F.L.
ISSN
1549-4713 (Electronic)
ISSN-L
0161-6420
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
122
Numéro
6
Pages
1173-1179
Langue
anglais
Notes
Publication types: ARTICLE
Résumé
PURPOSE: To evaluate the clinical characteristics of the 3 classifications of vitreous seeds in retinoblastoma-dust (class 1), spheres (class 2), and clouds (class 3)-and their responses to intravitreal melphalan.
DESIGN: Retrospective, bi-institutional cohort study.
PARTICIPANTS: A total of 87 patient eyes received 475 intravitreal injections of melphalan (median dose, 30 μg) given weekly, a median of 5 times (range, 1-12 times).
METHODS: At presentation, the vitreous seeds were classified into 3 groups: dust, spheres, and clouds. Indirect ophthalmoscopy, fundus photography, ultrasonography, and ultrasonic biomicroscopy were used to evaluate clinical response to weekly intravitreal melphalan injections and time to regression of vitreous seeds. Kaplan-Meier estimates of time to regression and ocular survival, patient survival, and event-free survival (EFS) were calculated and then compared using the Mantel-Cox test of curve.
MAIN OUTCOME MEASURES: Time to regression of vitreous seeds, patient survival, ocular survival, and EFS.
RESULTS: The difference in time to regression was significantly different for the 3 seed classes (P < 0.0001): the median time to regression was 0.6, 1.7, and 7.7 months for dust, spheres, and clouds, respectively. Eyes with dust received significantly fewer injections and a lower median and cumulative dose of melphalan, whereas eyes with clouds received significantly more injections and a higher median and cumulative dose of melphalan. Overall, the 2-year Kaplan-Meier estimates for ocular survival, patient survival, and EFS (related to target seeds) were 90.4% (95% confidence interval [CI], 79.7-95.6), 100%, and 98.5% (95% CI, 90-99.7), respectively.
CONCLUSIONS: The regression and response of vitreous seeds to intravitreal melphalan are different for each seed classification. The vitreous seed classification can be predictive of time to regression, number, median dose, and cumulative dose of intravitreal melphalan injections required.
Pubmed
Web of science
Création de la notice
24/03/2015 11:42
Dernière modification de la notice
20/08/2019 14:38
Données d'usage