Assessing the perioperative gain of weight (Δweight) as a determinant of morbidity after kidney transplantation: a retrospective exploratory study.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_7D2856ED2C2A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Assessing the perioperative gain of weight (Δweight) as a determinant of morbidity after kidney transplantation: a retrospective exploratory study.
Journal
Scientific reports
Author(s)
Carbonell B.B., Zingg T., Matter M., Joliat G.R., Martin D., Pascual M., Demartines N., Golshayan D., Cano L., Labgaa I.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Publication state
Published
Issued date
11/06/2024
Peer-reviewed
Oui
Volume
14
Number
1
Pages
13384
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Kidney transplantation (KT) is associated with a substantial risk of postoperative complications (POC) for which performant predictors are lacking. Data showed that a perioperative gain of weight (ΔWeight) was associated with higher risk of POC, but it remains unexplored in KT. This retrospective study aimed to investigate the association between ΔWeight and POC after KT. ΔWeight was calculated on postoperative day (POD) 2. POC were graded according to the Dindo-Clavien classification. Primary endpoint was overall POC. A total of 242 patients were included and 174 (71.9%) complications were reported. Patients showed a rapid gain of weight after KT. Mean ΔWeight was 7.83 kg (± 3.20) compared to 5.3 kg (± 3.56) in patients with and without complication, respectively (p = 0.0005). ΔWeight showed an accuracy of 0.74 for overall POC. A cut-off of 8.5 kg was determined. ΔWeight ≥ 8.5 kg was identified as an independent predictor of overall POC on multivariable analysis (OR 2.04; 95% CI 1.08-3.84; p = 0.025). ΔWeight ≥ 8.5 kg appeared as an independent predictor of POC after KT. These results stress the need to monitor weight in KT and to further investigate this surrogate with future studies assessing its clinical relevance.
Keywords
Humans, Kidney Transplantation/adverse effects, Female, Male, Retrospective Studies, Middle Aged, Postoperative Complications/etiology, Postoperative Complications/epidemiology, Weight Gain, Adult, Perioperative Period, Risk Factors, Aged, Biomarkers, Complications, Outcomes, Prediction, Transplant
Pubmed
Web of science
Open Access
Yes
Create date
13/06/2024 16:30
Last modification date
29/10/2024 7:21
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