TIE-2 expressing monocytes in human cancers.

Détails

Ressource 1Télécharger: koni-06-04-1303585.pdf (697.68 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_7D0E518DFF81
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
TIE-2 expressing monocytes in human cancers.
Périodique
Oncoimmunology
Auteur(s)
Turrini R., Pabois A., Xenarios I., Coukos G., Delaloye J.F., Doucey M.A.
ISSN
2162-4011 (Print)
ISSN-L
2162-4011
Statut éditorial
Publié
Date de publication
2017
Peer-reviewed
Oui
Volume
6
Numéro
4
Pages
e1303585
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Tumor-associated macrophages (TAM) are well known as a key player in the tumor microenvironment, which support cancer progression. More recently, a lineage of monocytes characterized by the expression of the TIE-2/Tek angiopoietin receptor identified a subset of circulating and tumor-associated monocytes endowed with proangiogenic activity. TIE-2 expressing monocytes (TEM) were found both in humans and mice. Here, we review the phenotypes and functions of TEM reported so far in human cancer and their potential use as markers of cancer progression and metastasis. Finally, we discuss the therapeutic approaches currently used or proposed to target TEM.

Pubmed
Web of science
Open Access
Oui
Création de la notice
23/05/2017 16:26
Dernière modification de la notice
20/08/2019 14:38
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