Supercritical fluid extraction of drugs in drug addict hair.
Details
Serval ID
serval:BIB_7D0233425AB1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Supercritical fluid extraction of drugs in drug addict hair.
Journal
Journal of Chromatography. B, Biomedical Applications
ISSN
1572-6495[print], 1572-6495[linking]
Publication state
Published
Issued date
1995
Volume
673
Number
2
Pages
173-181
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
Opiates were extracted from sixteen hair samples of drug addicts using a supercritical fluid extraction method with supercritical carbon dioxide and a modifier solution of methanol-triethylamine-water (2:2:1, v/v). the concentrations, as determined by GC-MS, ranged from 1.22 to 21.73 (mean 7.60 ng/mg), 0.17 to 1.54 (mean 0.69 ng/mg) and 0.15 to 14.009 ng/mg hair (mean 3.78 ng/mg) for codeine, morphine and 6-monoacetylmorphine, respectively. The reproducibility of the total procedure had a relative standard deviation of 13%, 17% and 14% for codeine, morphine and 6-monoacetylmorphine, respectively. But this method, concentrations of 0.3, 0.2 and 0.1 ng/mg hair for codeine, morphine and 6-monoacetylmorphine, respectively, could be detected. Relative extraction recoveries were 61%, 53% and 96% for codeine, morphine and 6-monoacetylmorphine, respectively.
Keywords
Cannabinoids/analysis, Carbon Dioxide, Cocaine/analysis, Codeine/analysis, Codeine/isolation & purification, Ethylamines, Gas Chromatography-Mass Spectrometry, Hair/chemistry, Humans, Methanol, Morphine/analysis, Morphine/isolation & purification, Morphine Derivatives/analysis, Morphine Derivatives/isolation & purification, Narcotics/isolation & purification, Opioid-Related Disorders, Reproducibility of Results, Solutions, Temperature, Water
Pubmed
Create date
19/10/2010 16:31
Last modification date
20/08/2019 15:38