Insertion/deletion and nucleotide polymorphism data reveal constraints in Drosophila melanogaster introns and intergenic regions.

Détails

ID Serval
serval:BIB_7CFF00535A14
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Insertion/deletion and nucleotide polymorphism data reveal constraints in Drosophila melanogaster introns and intergenic regions.
Périodique
Genetics
Auteur(s)
Ometto L., Stephan W., De Lorenzo D.
ISSN
0016-6731
Statut éditorial
Publié
Date de publication
2005
Peer-reviewed
Oui
Volume
169
Numéro
3
Pages
1521-1527
Langue
anglais
Résumé
Our study of nucleotide sequence and insertion/deletion polymorphism in Drosophila melanogaster noncoding DNA provides evidence for selective pressures in both intergenic regions and introns (of the large size class). Intronic and intergenic sequences show a similar polymorphic deletion bias. Insertions have smaller sizes and higher frequencies than deletions, supporting the hypothesis that insertions are selected to compensate for the loss of DNA caused by deletion bias. Analysis of a simple model of selective constraints suggests that the blocks of functional elements located in intergenic sequences are on average larger than those in introns, while the length distribution of relatively unconstrained sequences interspaced between these blocks is similar in intronic and intergenic regions.
Mots-clé
Animals, DNA Transposable Elements, Drosophila melanogaster/genetics, Introns, Models, Genetic, Polymorphism, Genetic, Sequence Deletion, Species Specificity
Pubmed
Web of science
Création de la notice
19/11/2007 10:35
Dernière modification de la notice
20/08/2019 14:38
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