Gene expression across mammalian organ development.

Détails

ID Serval
serval:BIB_7CF7C4B1B63D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Gene expression across mammalian organ development.
Périodique
Nature
Auteur(s)
Cardoso-Moreira M., Halbert J., Valloton D., Velten B., Chen C., Shao Y., Liechti A., Ascenção K., Rummel C., Ovchinnikova S., Mazin P.V., Xenarios I., Harshman K., Mort M., Cooper D.N., Sandi C., Soares M.J., Ferreira P.G., Afonso S., Carneiro M., Turner JMA, VandeBerg J.L., Fallahshahroudi A., Jensen P., Behr R., Lisgo S., Lindsay S., Khaitovich P., Huber W., Baker J., Anders S., Zhang Y.E., Kaessmann H.
ISSN
1476-4687 (Electronic)
ISSN-L
0028-0836
Statut éditorial
Publié
Date de publication
07/2019
Peer-reviewed
Oui
Volume
571
Numéro
7766
Pages
505-509
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
The evolution of gene expression in mammalian organ development remains largely uncharacterized. Here we report the transcriptomes of seven organs (cerebrum, cerebellum, heart, kidney, liver, ovary and testis) across developmental time points from early organogenesis to adulthood for human, rhesus macaque, mouse, rat, rabbit, opossum and chicken. Comparisons of gene expression patterns identified correspondences of developmental stages across species, and differences in the timing of key events during the development of the gonads. We found that the breadth of gene expression and the extent of purifying selection gradually decrease during development, whereas the amount of positive selection and expression of new genes increase. We identified differences in the temporal trajectories of expression of individual genes across species, with brain tissues showing the smallest percentage of trajectory changes, and the liver and testis showing the largest. Our work provides a resource of developmental transcriptomes of seven organs across seven species, and comparative analyses that characterize the development and evolution of mammalian organs.
Mots-clé
Animals, Biological Evolution, Chickens/genetics, Female, Gene Expression Regulation, Developmental, Humans, Macaca mulatta/genetics, Male, Mice, Opossums/genetics, Organogenesis/genetics, Rabbits, Rats, Transcriptome/genetics
Pubmed
Web of science
Création de la notice
18/07/2019 17:31
Dernière modification de la notice
24/09/2019 5:26
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