Cost-Effectiveness of Nalmefene Added to Psychosocial Support for the Reduction of Alcohol Consumption in Alcohol-Dependent Patients With High/Very High Drinking Risk Levels: A Microsimulation Model.

Détails

ID Serval
serval:BIB_7C58FCF8342C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Cost-Effectiveness of Nalmefene Added to Psychosocial Support for the Reduction of Alcohol Consumption in Alcohol-Dependent Patients With High/Very High Drinking Risk Levels: A Microsimulation Model.
Périodique
Journal of studies on alcohol and drugs
Auteur(s)
Millier A., Laramée P., Rahhali N., Aballéa S., Daeppen J.B., Rehm J., Toumi M.
ISSN
1938-4114 (Electronic)
ISSN-L
1937-1888
Statut éditorial
Publié
Date de publication
11/2017
Peer-reviewed
Oui
Volume
78
Numéro
6
Pages
867-876
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
A microsimulation model was adapted to evaluate the cost-effectiveness of nalmefene combined with psychosocial support (NMF + PS) versus psychosocial support alone (PS). The economic impact of alcohol reduction using nalmefene treatment was not evaluated.
The model simulates patient-level alcohol consumption over a 5-year time horizon across different treatment cohorts. Study outcomes included probabilities of alcohol-attributable diseases and injuries as well as deaths from these events. The approach used nalmefene clinical trial data, a time horizon of 1 and 5 years, and a U.K. societal perspective. Extensive deterministic and probabilistic sensitivity analyses were conducted.
Compared with the PS strategy, NMF + PS was associated at Year 5 with a gain of 0.047 quality-adjusted life years (QALYs) and an additional £503, leading to an incremental cost-effectiveness ratio (ICER) of £10,613 per QALY gained. When compared with the strategy without treatment, NMF + PS was associated with a gain of 0.228 QALYs and an additional £1,795, leading to an ICER of £1,758 per QALY gained. The NMF + PS strategy dominated both treatment strategies when considering the U.K. societal perspective. Sensitivity analyses confirmed the robustness of the results.
A combination of NMF and PS was better than PS alone, considering a 5-year time horizon and a societal perspective.

Mots-clé
Alcohol Drinking/economics, Alcohol Drinking/prevention & control, Alcoholism/therapy, Cost-Benefit Analysis, Female, Humans, Male, Middle Aged, Naltrexone/administration & dosage, Naltrexone/analogs & derivatives, Quality-Adjusted Life Years, Risk
Pubmed
Web of science
Création de la notice
09/11/2017 18:20
Dernière modification de la notice
26/04/2018 20:06
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