Iodine-123 metaiodobenzylguanidine scintigraphy and iodine-123 ioflupane single photon emission computed tomography in Lewy body diseases: complementary or alternative techniques?

Détails

ID Serval
serval:BIB_7C3239C86EF4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Iodine-123 metaiodobenzylguanidine scintigraphy and iodine-123 ioflupane single photon emission computed tomography in Lewy body diseases: complementary or alternative techniques?
Périodique
Journal of neuroimaging
Auteur(s)
Treglia G., Cason E., Cortelli P., Gabellini A., Liguori R., Bagnato A., Giordano A., Fagioli G.
ISSN
1552-6569 (Electronic)
ISSN-L
1051-2284
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
24
Numéro
2
Pages
149-154
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
To compare myocardial sympathetic imaging using (123)I-Metaiodobenzylguanidine (MIBG) scintigraphy and striatal dopaminergic imaging using (123)I-Ioflupane (FP-CIT) single photon emission computed tomography (SPECT) in patients with suspected Lewy body diseases (LBD).
Ninety-nine patients who performed both methods within 2 months for differential diagnosis between Parkinson's disease (PD) and other parkinsonism (n = 68) or between dementia with Lewy bodies (DLB) and other dementia (n = 31) were enrolled. Sensitivity, specificity, accuracy, positive and negative predictive values of both methods were calculated.
For (123) I-MIBG scintigraphy, the overall sensitivity, specificity, accuracy, positive and negative predictive values in LBD were 83%, 79%, 82%, 86%, and 76%, respectively. For (123)I-FP-CIT SPECT, the overall sensitivity, specificity, accuracy, positive and negative predictive values in LBD were 93%, 41%, 73%, 71%, and 80%, respectively. There was a statistically significant difference between these two methods in patients without LBD, but not in patients with LBD.
LBD usually present both myocardial sympathetic and striatal dopaminergic impairments. (123)I-FP-CIT SPECT presents high sensitivity in the diagnosis of LBD; (123)I-MIBG scintigraphy may have a complementary role in differential diagnosis between PD and other parkinsonism. These scintigraphic methods showed similar diagnostic accuracy in differential diagnosis between DLB and other dementia.

Mots-clé
3-Iodobenzylguanidine, Aged, Aged, 80 and over, Female, Humans, Lewy Body Disease/diagnostic imaging, Male, Middle Aged, Radiopharmaceuticals, Reproducibility of Results, Sensitivity and Specificity, Tomography, Emission-Computed, Single-Photon/methods, Tropanes, Ioflupane, Lewy body disease, Metaiodobenzylguanidine, Parkinson's disease, dementia with Lewy bodies, nuclear medicine
Pubmed
Web of science
Création de la notice
20/08/2017 21:14
Dernière modification de la notice
03/03/2018 18:37
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