Effect of indomethacin and propranolol on the blood pressure and renin response to atriopeptin III in conscious rats
Details
Serval ID
serval:BIB_7C12186693D2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effect of indomethacin and propranolol on the blood pressure and renin response to atriopeptin III in conscious rats
Journal
Regulatory Peptides
ISSN
0167-0115 (Print)
Publication state
Published
Issued date
05/1987
Volume
17
Number
5
Pages
277-84
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: May
Research Support, Non-U.S. Gov't --- Old month value: May
Abstract
The effect of prostaglandin synthesis inhibition and of beta-adrenoceptor blockade on the blood pressure and renin response to the synthetic atrial natriuretic peptide atriopeptin III was assessed in unanesthetized normotensive rats. This peptide was infused i.v. for 30 min at a rate of 1 microgram/min in rats pretreated either with indomethacin (5 mg i.v.) or propranolol (1 mg i.v.). The blood pressure reducing effect of atriopeptin III was attenuated neither by indomethacin nor by propranolol. Atriopeptin III per se did not modify plasma renin activity. Both the administration of indomethacin and of propranolol had a suppressing effect on renin release during atriopeptin III infusion. These data suggest that the vasodilating properties of atrial natriuretic peptides do not depend in the conscious normotensive rats on the production of prostaglandins. They also provide evidence that during infusion of such peptides, both prostaglandins and beta-adrenergic mechanisms are still involved in the regulation of renin secretion.
Keywords
Animals
Atrial Natriuretic Factor/*pharmacology
Blood Pressure/*drug effects
Heart Rate/drug effects
Indomethacin/*pharmacology
Male
Propranolol/*pharmacology
Prostaglandins/physiology
Rats
Rats, Inbred Strains
Receptors, Adrenergic, beta/physiology
Renin/*blood
Pubmed
Web of science
Create date
05/03/2008 17:39
Last modification date
20/08/2019 15:37