Genomewide association study using a high-density single nucleotide polymorphism array and case-control design identifies a novel essential hypertension susceptibility locus in the promoter region of endothelial NO synthase.

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Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_7BFB71DF48D8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Genomewide association study using a high-density single nucleotide polymorphism array and case-control design identifies a novel essential hypertension susceptibility locus in the promoter region of endothelial NO synthase.
Périodique
Hypertension
Auteur(s)
Salvi E., Kutalik Z., Glorioso N., Benaglio P., Frau F., Kuznetsova T., Arima H., Hoggart C., Tichet J., Nikitin Y.P., Conti C., Seidlerova J., Tikhonoff V., Stolarz-Skrzypek K., Johnson T., Devos N., Zagato L., Guarrera S., Zaninello R., Calabria A., Stancanelli B., Troffa C., Thijs L., Rizzi F., Simonova G., Lupoli S., Argiolas G., Braga D., D'Alessio M.C., Ortu M.F., Ricceri F., Mercurio M., Descombes P., Marconi M., Chalmers J., Harrap S., Filipovsky J., Bochud M., Iacoviello L., Ellis J., Stanton A.V., Laan M., Padmanabhan S., Dominiczak A.F., Samani N.J., Melander O., Jeunemaitre X., Manunta P., Shabo A., Vineis P., Cappuccio F.P., Caulfield M.J., Matullo G., Rivolta C., Munroe P.B., Barlassina C., Staessen J.A., Beckmann J.S., Cusi D.
ISSN
1524-4563 (Electronic)
ISSN-L
0194-911X
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
59
Numéro
2
Pages
248-255
Langue
anglais
Résumé
Essential hypertension is a multifactorial disorder and is the main risk factor for renal and cardiovascular complications. The research on the genetics of hypertension has been frustrated by the small predictive value of the discovered genetic variants. The HYPERGENES Project investigated associations between genetic variants and essential hypertension pursuing a 2-stage study by recruiting cases and controls from extensively characterized cohorts recruited over many years in different European regions. The discovery phase consisted of 1865 cases and 1750 controls genotyped with 1M Illumina array. Best hits were followed up in a validation panel of 1385 cases and 1246 controls that were genotyped with a custom array of 14 055 markers. We identified a new hypertension susceptibility locus (rs3918226) in the promoter region of the endothelial NO synthase gene (odds ratio: 1.54 [95% CI: 1.37-1.73]; combined P=2.58 · 10(-13)). A meta-analysis, using other in silico/de novo genotyping data for a total of 21 714 subjects, resulted in an overall odds ratio of 1.34 (95% CI: 1.25-1.44; P=1.032 · 10(-14)). The quantitative analysis on a population-based sample revealed an effect size of 1.91 (95% CI: 0.16-3.66) for systolic and 1.40 (95% CI: 0.25-2.55) for diastolic blood pressure. We identified in silico a potential binding site for ETS transcription factors directly next to rs3918226, suggesting a potential modulation of endothelial NO synthase expression. Biological evidence links endothelial NO synthase with hypertension, because it is a critical mediator of cardiovascular homeostasis and blood pressure control via vascular tone regulation. This finding supports the hypothesis that there may be a causal genetic variation at this locus.
Pubmed
Web of science
Open Access
Oui
Création de la notice
21/12/2011 16:27
Dernière modification de la notice
08/05/2019 20:51
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