Transgenic mice and their impact on kidney research.

Détails

Ressource 1Télécharger: serval:BIB_7BABD3B1F0E9.P001 (345.49 [Ko])
Etat: Public
Version: de l'auteur
Licence: Non spécifiée
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
ID Serval
serval:BIB_7BABD3B1F0E9
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Transgenic mice and their impact on kidney research.
Périodique
Pflügers Archiv
Auteur(s)
Rubera I., Hummler E., Beermann F.
ISSN
1432-2013[electronic]
Statut éditorial
Publié
Date de publication
12/2009
Volume
458
Numéro
1
Pages
211-222
Langue
anglais
Résumé
The kidney is a key organ in the maintenance of ion and fluid homeostasis and specific transport systems localized along the nephron guarantee this function. Due to its large functional heterogeneity, experiments on the whole organ level cannot be easily performed, and thus more refined tools are needed, like for example the development of specific recombination systems to gain knowledge on the physiological role of single proteins implicated in ion transport. This review introduces the transgenic technology developed over the past decades, and then focuses on recent strategies for generating kidney-specific gene targeting, over-expression, and gene ablation in mice, that will help to understand the physiological role of proteins implicated in salt and water balance in the kidney.
Mots-clé
Animals, Aquaporin 2/genetics, Disease Models, Animal, Embryonic Stem Cells/transplantation, Epithelial Sodium Channel/genetics, Genetic Engineering, Genetic Vectors/physiology, Humans, Integrases/metabolism, Kidney/physiology, Kidney Diseases/genetics, Kidney Diseases/physiopathology, Lentivirus/genetics, Mice, Mice, Knockout, Mice, Transgenic, Transgenes/physiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
18/03/2009 9:56
Dernière modification de la notice
01/10/2019 6:18
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