Zika virus, vaccines, and antiviral strategies.

Détails

ID Serval
serval:BIB_7B9120567621
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Zika virus, vaccines, and antiviral strategies.
Périodique
Expert review of anti-infective therapy
Auteur(s)
Masmejan S., Baud D., Musso D., Panchaud A.
ISSN
1744-8336 (Electronic)
ISSN-L
1478-7210
Statut éditorial
Publié
Date de publication
06/2018
Peer-reviewed
Oui
Volume
16
Numéro
6
Pages
471-483
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Zika virus (ZIKV) recently emerged as a global public health emergency of international concern. ZIKV is responsible for severe neurological complications in adults and infection during pregnancy and can lead to congenital Zika syndrome. There is no licensed vaccine or drug to prevent or treat ZIKV infection. Areas covered: The aim of this article is to provide an overview and update of the progress of research on anti-ZIKV vaccine and medications until the end of 2017, with a special emphasis on drugs that can be used during pregnancy. Expert commentary: Development of new vaccines and drugs is challenging and several points particular to ZIKV infections augment this difficulty: (1) Cross-reactions between ZIKV and other flaviviruses, the impact of ZIKV vaccination on subsequent flavivirus infections, and vice-versa, is unknown, (2) Drugs against ZIKV should be safe in pregnant women, and (3) Evaluation of the efficacy of vaccine and drugs against ZIKV in clinical trials phase II-IV will be complicated due to the decline of ZIKV circulation.
Mots-clé
Adult, Animals, Antiviral Agents/administration & dosage, Antiviral Agents/adverse effects, Drug Design, Female, Humans, Infectious Disease Transmission, Vertical/prevention & control, Pregnancy, Pregnancy Complications, Infectious/virology, Vaccination/methods, Viral Vaccines/administration & dosage, Zika Virus Infection/complications, Zika Virus Infection/epidemiology, Zika Virus Infection/prevention & control, Antiviral, ZIKV, arbovirus, drugs, emerging diseases, fetus, flavivirus, microcephaly, pregnancy, vaccine, zika virus
Pubmed
Web of science
Création de la notice
25/06/2018 9:47
Dernière modification de la notice
07/02/2019 7:26
Données d'usage