Sex differences in symptom patterns of recurrent major depression in siblings

Détails

ID Serval
serval:BIB_7B871D3EA5E4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Sex differences in symptom patterns of recurrent major depression in siblings
Périodique
Depression and Anxiety
Auteur(s)
Moskvina Valentina, Farmer Anne, Jones Ian Richard, Brewster Shyama, Ferrero François, Gill Michael, Jones Lisa Anne, Maier Wolfgang, Mors Ole, Owen Mike J., Perry Julia, Preisig Martin, Rietschel Marcella, McGuffin Peter, Craddock Nick, Korszung Ania
ISSN
1091-4269
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
25
Numéro
6
Pages
527-534
Langue
anglais
Notes
SAPHIRID:69931
Résumé
The objectives of this study were to examine sex differences in depressive symptom patterns in 475 sib pairs with well-defined recurrent major depression and to test the hypotheses that (a) symptom patterns show higher intraclass correlations within same sex sib pairs versus mixed sex sib pairs; and (b) symptoms more associated with women, e.g. atypical depressive and anxiety symptoms, account for differences between male and female siblings within the same family. A total of 878 individuals, with a past history of at least two depressive episodes, were interviewed using the Schedules for Clinical Assessment in Neuropsychiatry interview and diagnosed according to DSM-IV using a computerized scoring program (CATEGO5). Intraclass correlations were compared between mixed and same sex sibs, and a conditional regression analysis in mixed sex sib pairs was performed to test whether specific symptoms account for differences between male and female siblings within the same family. Women showed a significantly earlier onset of depression compared with men (23.0 years, SD=10.6 versus 25.5, SD=12.5 years, P=0.0004), and a significantly greater frequency of several aspects of depressed mood was found in women compared with men, including atypical depressive features of fatiguability, appetite gain, weight gain and hypersomnia. Discordant sib-pair data analyses revealed five symptoms that accounted for the sex differences between siblings (P=.000035): phobia (exp(B)=2.04, P=0.017), hypersomnia (exp(B)=1.37, P=0.055), appetite loss (exp(B)=1.38, P=0.004) and appetite gain (exp(B)=2.19, P<0.001). Sex significantly modifies clinical features of depression and an earlier onset of depression and atypical depressive symptoms occur more frequently in women.
Pubmed
Web of science
Création de la notice
03/10/2008 16:27
Dernière modification de la notice
20/08/2019 15:37
Données d'usage