Motor practice and neurophysiological adaptation in the cerebellum: a positron tomography study.

Details

Serval ID
serval:BIB_7B85703868EF
Type
Article: article from journal or magazin.
Collection
Publications
Title
Motor practice and neurophysiological adaptation in the cerebellum: a positron tomography study.
Journal
Proceedings of the Royal Society B Biological Sciences
Author(s)
Friston K.J., Frith C.D., Passingham R.E., Liddle P.F., Frackowiak R.S.
ISSN
0962-8452 (Print)
ISSN-L
0962-8452
Publication state
Published
Issued date
1992
Volume
248
Number
1323
Pages
223-228
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
We have used positron tomography (PET) to demonstrate that some parts of the motor system exhibit physiological adaptation during the repeated performance of a simple motor task, but others do not. In contrast to the primary sensori-motor cortex, the cerebellum exhibits a decrease in physiological activation (increases in regional blood flow during performance) with practice. A new application of factorial experimental design to PET activation studies was used to make these measurements in four normal males. This design allowed adaptation to be examined by testing for an interaction between regional cerebral blood flow (rCBF) increases brought about by a motor task and the number of trials (time). These findings are interpreted as the neurophysiological correlates of synaptic changes in the cerebellum associated with motor learning in man.
Keywords
Adaptation, Physiological, Adult, Cerebellum/physiology, Cerebrovascular Circulation/physiology, Humans, Male, Neurophysiology, Psychomotor Performance/physiology, Synapses/physiology, Tomography, Emission-Computed
Pubmed
Web of science
Create date
25/09/2011 16:14
Last modification date
20/08/2019 14:37
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