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Muscle fatigue: from observations in humans to underlying mechanisms studied in intact single muscle fibres.
European Journal of Applied Physiology
Prolonged dynamic exercise and sustained isometric contractions induce muscle fatigue, as manifested by decreased performance and a reduction in the maximum voluntary contraction force. Studies with non-invasive measurements in exercising humans show that mechanisms located beyond the sarcolemma are important in the fatigue process. In this review, we describe probable cellular mechanisms underlying fatigue-induced changes in excitation-contraction (E-C) coupling occurring in human muscle fibres during strenuous exercise. We use fatigue-induced changes observed in intact single muscle fibres, where force and cellular Ca(2+) handling can be directly measured, to explain changes in E-C coupling observed in human muscle during exercise.
Excitation Contraction Coupling, Humans, Isometric Contraction, Muscle Fatigue, Muscle Fibers, Skeletal/metabolism, Muscle Fibers, Skeletal/physiology, Muscle Strength, Muscle, Skeletal/innervation, Muscle, Skeletal/metabolism, Recovery of Function, Time Factors
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