Hypertension in a Patient With Polycystic Kidney Disease Complicated by Concomitant Pheochromocytoma.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_7B764FF92092
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Hypertension in a Patient With Polycystic Kidney Disease Complicated by Concomitant Pheochromocytoma.
Journal
AACE clinical case reports
Author(s)
Ameti A., Kopp P.A., Pitteloud N., Wuerzner G., Grouzmann E., Matter M., Lamine F., Phan O.
ISSN
2376-0605 (Electronic)
ISSN-L
2376-0605
Publication state
Published
Issued date
2024
Peer-reviewed
Oui
Volume
10
Number
4
Pages
136-139
Language
english
Notes
Publication types: Case Reports ; Journal Article
Publication Status: epublish
Abstract
Due to the high prevalence of hypertension in patients with autosomal dominant polycystic kidney disease (ADPKD) and advanced chronic kidney disease, diagnosing secondary hypertension poses challenges. We present a rare case of pheochromocytoma in an ADPKD patient to highlight the diagnostic difficulties in identifying secondary hypertension due to pheochromocytoma/paraganglioma (PPGL) in end-stage renal disease (ESRD) patients.
A 48-year-old female with ADPKD and ESRD experienced recurrent hypertensive crises (up to 220/135 mmHg) accompanied by palpitations and tremors that recurred over the past 2 years. Introduction of a betablocker to the antihypertensive therapy aggravated her symptoms. The initial documentation of elevated urinary metanephrines was interpreted as false positive finding due to renal failure. Subsequent measurements of free plasma metanephrines revealed significant elevations raising suspicion of PPGL. Magnetic resonance imaging identified a 29 mm right adrenal mass. The patient underwent right adrenalectomy resulting in resolution of the hypertensive crises.
The diagnosis of PPGLs can present significant challenges and is further complicated in ESRD due to nonspecific clinical symptoms and diagnostic pitfalls. Less than 20 PPGL cases have been reported in patients with ESRD. The intolerance of beta-blocker therapy, as well as the use of a scoring system for the likelihood of PPGL should have raised suspicion.
PPGL should be considered in all patients with uncontrolled hypertension and beta-blockers intolerance, even in the presence of other etiologic mechanisms such as ESRD. Measuring free plasma metanephrines provides the most reliable biochemical screening in the context of impaired renal function.
Keywords
autosomal dominant polycystic disease, catecholamines, hypertension, metanephrines, pheochromocytoma
Pubmed
Web of science
Open Access
Yes
Create date
25/07/2024 12:50
Last modification date
10/08/2024 6:30
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