Article: article from journal or magazin.
Activation of reward circuitry in human opiate addicts.
European Journal of Neuroscience
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
The neurobiological mechanisms of opiate addictive behaviour in humans are unknown. A proposed model of addiction implicates ascending brainstem neuromodulatory systems, particularly dopamine. Using functional neuroimaging, we assessed the neural response to heroin and heroin-related cues in established opiate addicts. We show that the effect of both heroin and heroin-related visual cues are maximally expressed in the sites of origin of ascending midbrain neuromodulatory systems. These context-specific midbrain activations predict responses to salient visual cues in cortical and subcortical regions implicated in reward-related behaviour. These findings implicate common neurobiological processes underlying drug and drug-cue-related effects.
Adult, Brain Chemistry/drug effects, Brain Stem/cytology, Brain Stem/drug effects, Heroin/administration & dosage, Heroin Dependence/physiopathology, Heroin Dependence/radionuclide imaging, Humans, Interneurons/chemistry, Interneurons/drug effects, Male, Mesencephalon/cytology, Mesencephalon/drug effects, Narcotics/administration & dosage, Neural Pathways, Pain Measurement, Parietal Lobe/cytology, Parietal Lobe/drug effects, Photic Stimulation, Reward, Tomography, Emission-Computed, gamma-Aminobutyric Acid/physiology
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