Activation of reward circuitry in human opiate addicts.

Détails

ID Serval
serval:BIB_7B708703584C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Activation of reward circuitry in human opiate addicts.
Périodique
European Journal of Neuroscience
Auteur(s)
Sell L.A., Morris J., Bearn J., Frackowiak R.S., Friston K.J., Dolan R.J.
ISSN
0953-816X (Print)
ISSN-L
0953-816X
Statut éditorial
Publié
Date de publication
1999
Volume
11
Numéro
3
Pages
1042-1048
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
The neurobiological mechanisms of opiate addictive behaviour in humans are unknown. A proposed model of addiction implicates ascending brainstem neuromodulatory systems, particularly dopamine. Using functional neuroimaging, we assessed the neural response to heroin and heroin-related cues in established opiate addicts. We show that the effect of both heroin and heroin-related visual cues are maximally expressed in the sites of origin of ascending midbrain neuromodulatory systems. These context-specific midbrain activations predict responses to salient visual cues in cortical and subcortical regions implicated in reward-related behaviour. These findings implicate common neurobiological processes underlying drug and drug-cue-related effects.
Mots-clé
Adult, Brain Chemistry/drug effects, Brain Stem/cytology, Brain Stem/drug effects, Heroin/administration & dosage, Heroin Dependence/physiopathology, Heroin Dependence/radionuclide imaging, Humans, Interneurons/chemistry, Interneurons/drug effects, Male, Mesencephalon/cytology, Mesencephalon/drug effects, Narcotics/administration & dosage, Neural Pathways, Pain Measurement, Parietal Lobe/cytology, Parietal Lobe/drug effects, Photic Stimulation, Reward, Tomography, Emission-Computed, gamma-Aminobutyric Acid/physiology
Pubmed
Web of science
Création de la notice
16/09/2011 17:16
Dernière modification de la notice
03/03/2018 18:35
Données d'usage