Nonstructural protein 3-4A: the Swiss army knife of hepatitis C virus.

Détails

ID Serval
serval:BIB_7B6F801D3994
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Nonstructural protein 3-4A: the Swiss army knife of hepatitis C virus.
Périodique
Journal of Viral Hepatitis
Auteur(s)
Morikawa K., Lange C.M., Gouttenoire J., Meylan E., Brass V., Penin F., Moradpour D.
ISSN
1365-2893 (Electronic)
ISSN-L
1352-0504
Statut éditorial
Publié
Date de publication
2011
Volume
18
Numéro
5
Pages
305-315
Langue
anglais
Résumé
Summary.  Hepatitis C virus (HCV) nonstructural protein 3-4A (NS3-4A) is a complex composed of NS3 and its cofactor NS4A. It harbours serine protease as well as NTPase/RNA helicase activities and is essential for viral polyprotein processing, RNA replication and virion formation. Specific inhibitors of the NS3-4A protease significantly improve sustained virological response rates in patients with chronic hepatitis C when combined with pegylated interferon-α and ribavirin. The NS3-4A protease can also target selected cellular proteins, thereby blocking innate immune pathways and modulating growth factor signalling. Hence, NS3-4A is not only an essential component of the viral replication complex and prime target for antiviral intervention but also a key player in the persistence and pathogenesis of HCV. This review provides a concise update on the biochemical and structural aspects of NS3-4A, its role in the pathogenesis of chronic hepatitis C and the clinical development of NS3-4A protease inhibitors.
Pubmed
Web of science
Création de la notice
26/04/2011 15:14
Dernière modification de la notice
20/08/2019 15:37
Données d'usage