Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8T cell development.

Détails

ID Serval
serval:BIB_7B6F739C3164
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8T cell development.
Périodique
Nature immunology
Auteur(s)
Wolfer A., Bakker T., Wilson A., Nicolas M., Ioannidis V., Littman D.R., Lee P.P., Wilson C.B., Held W., MacDonald H.R., Radtke F.
ISSN
1529-2908
Statut éditorial
Publié
Date de publication
2001
Peer-reviewed
Oui
Volume
2
Numéro
3
Pages
235-241
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Notch proteins influence cell-fate decisions in many developing systems. Several gain-of-function studies have suggested a critical role for Notch 1 signaling in CD4-CD8 lineage commitment, maturation and survival in the thymus. However, we show here that tissue-specific inactivation of the gene encoding Notch 1 in immature (CD25+CD44-)T cell precursors does not affect subsequent thymocyte development. Neither steady-state numbers nor the rate of production of CD4+ and CD8+ mature thymocytes is perturbed in the absence of Notch 1. In addition, Notch 1-deficient thymocytes are normally sensitive to spontaneous or glucocorticoid-induced apoptosis. In contrast to earlier reports, these data formally exclude an essential role for Notch 1 in CD4-CD8 lineage commitment, maturation or survival.
Mots-clé
Animals, Antigens, CD4/genetics, Apoptosis/drug effects, CD4-Positive T-Lymphocytes/drug effects, CD4-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/drug effects, CD8-Positive T-Lymphocytes/immunology, Cell Division, Cell Lineage, Cells, Cultured, Gene Deletion, Gene Targeting, Glucocorticoids/pharmacology, Integrases/genetics, Membrane Proteins/genetics, Membrane Proteins/physiology, Mice, Mice, Inbred C57BL, Mice, Knockout, Receptor, Notch1, Receptors, Cell Surface, Spleen/immunology, T-Lymphocyte Subsets/classification, Thymus Gland/cytology, Thymus Gland/immunology, Transcription Factors, Transgenes, Viral Proteins
Pubmed
Web of science
Création de la notice
28/01/2008 11:39
Dernière modification de la notice
20/08/2019 14:37
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