Molecular tools for the study of titin's differential expression

Détails

ID Serval
serval:BIB_7B4B521464B1
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Molecular tools for the study of titin's differential expression
Périodique
Advances in Experimental Medicine and Biology
Auteur(s)
Centner  T., Fougerousse  F., Freiburg  A., Witt  C., Beckmann  J. S., Granzier  H., Trombitas  K., Gregorio  C. C., Labeit  S.
ISSN
0065-2598 (Print)
Statut éditorial
Publié
Date de publication
2000
Volume
481
Pages
35-49; discussion 50-2
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review
Résumé
Although vertebrate genomes appear to contain only one titin gene, a large variety of quite distinct titin isoforms are expressed in striated muscle tissues. The isoforms appear to be generated by a series of complex, not yet fully characterized differential splicing mechanisms. Here, we provide an overview of the titin-specific antibodies that have been raised by our laboratory to study individual differentially expressed isoforms of titin. The staining patterns obtained in different tissues will contribute to the identification of both the particular titin isoforms that are expressed in the different tissues, as well as their intracellular distributions. In addition, antibodies to titin that are available are rapidly allowing for the refinement of our knowledge of titin's elastic spring properties. Knowledge of the nature and structure of vertebrate titins that may also be expressed in nonmuscle tissues may be broadened using these antibodies.
Mots-clé
Alternative Splicing Animals Elasticity Heart/physiology Humans Membrane Proteins/genetics Microfilaments/physiology Muscle Proteins/chemistry/*genetics/physiology Muscle, Skeletal/*physiology Protein Isoforms/chemistry/genetics/physiology Protein Kinases/chemistry/*genetics/physiology
Pubmed
Web of science
Création de la notice
25/01/2008 17:19
Dernière modification de la notice
03/03/2018 18:35
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