Therapeutic potential of endothelin receptor modulators: lessons from human clinical trials.

Détails

ID Serval
serval:BIB_7B4155B02DF6
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Therapeutic potential of endothelin receptor modulators: lessons from human clinical trials.
Périodique
Expert Opinion on Therapeutic Targets
Auteur(s)
Aubert J.D., Juillerat-Jeanneret L.
ISSN
1744-7631 (Electronic)
ISSN-L
1472-8222
Statut éditorial
Publié
Date de publication
2009
Volume
13
Numéro
9
Pages
1069-1084
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
The endothelin system, and in particular endothelin receptors, are targets for therapeutic intervention in human diseases. Endothelin receptor antagonists have reached clinical use for treating pulmonary arterial hypertension, and are under clinical investigation for several other diseases, such as cancer, vasospasm or fibrogenic diseases. We review the molecules that have been evaluated in the main clinical trials, from the point of view of receptor selectivity and of their chemical characteristics which were important for efficacy in pulmonary hypertension. We will also discuss future use of antagonists to endothelin receptor(s) in several human diseases and what should be the necessary properties of the future molecules for efficacy in diseases where the presently tested molecules displayed suboptimal efficacy.
Mots-clé
Animals, Clinical Trials as Topic, Drug Delivery Systems, Endothelins/metabolism, Humans, Hypertension, Pulmonary/drug therapy, Hypertension, Pulmonary/physiopathology, Neoplasms/drug therapy, Neoplasms/physiopathology, Receptors, Endothelin/antagonists & inhibitors
Pubmed
Web of science
Création de la notice
08/10/2009 14:32
Dernière modification de la notice
03/03/2018 18:35
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