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Photodynamic applications in superficial bladder cancer: facts and hopes!
Journal of Environmental Pathology, Toxicology and Oncology
As a disease characterized by a polymorphic and fluctuant nature in its evolution, superficial transitional cell carcinoma of the bladder remains a perpetual therapeutic challenge. This raises a great interest in the development of new diagnostic and therapeutic photodynamic applications. This article describes recent facts in the field of bladder cancer photodiagnosis and gives a survey on ongoing research in photodynamic therapy. Fluorescence cystoscopy induced by different aminolevulinic acid compounds (e.g., ALA-HAL) is well accepted in the urological community as a user-friendly new diagnostic tool in the endoscopic management of bladder tumors and CIS. Photodynamic therapy based on the same photosensitizing agents remains experimental, but recent results raise hopes of new therapeutic directions.
Aminolevulinic Acid/therapeutic use Animals Carcinoma, Transitional Cell/diagnosis/drug therapy Clinical Trials Cystoscopy Dihematoporphyrin Ether/therapeutic use Fluorescence Hematoporphyrin Derivative/therapeutic use Humans *Photochemotherapy Photosensitizing Agents/therapeutic use Urinary Bladder Neoplasms/*diagnosis/*drug therapy
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