Activation of the extracellular signal regulated kinase (ERK) pathway in human melanoma

Détails

ID Serval
serval:BIB_7B1695E1BE0D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Activation of the extracellular signal regulated kinase (ERK) pathway in human melanoma
Périodique
Journal of Clinical Pathology
Auteur(s)
Zhuang  L., Lee  C. S., Scolyer  R. A., McCarthy  S. W., Palmer  A. A., Zhang  X. D., Thompson  J. F., Bron  L. P., Hersey  P.
ISSN
0021-9746 (Print)
Statut éditorial
Publié
Date de publication
11/2005
Volume
58
Numéro
11
Pages
1163-9
Notes
Journal Article --- Old month value: Nov
Résumé
BACKGROUND: Several studies suggest that melanoma may be resistant to treatment because of resistance to apoptosis and that this may be the result of activation of the extracellular signal regulated kinase (ERK1/2) pathway. AIMS: To test this hypothesis by examining the expression of ERK1/2 and its activated form in histological sections of melanoma and its relation to known prognostic features of the disease. MATERIALS/METHODS: Immunohistochemistry with antibodies to ERK1/2 and phosphorylated ERK (p-ERK) was performed on formalin fixed sections from 42 primary melanomas, 38 metastases, and 20 naevi. Fourteen of the primary melanomas were in the radial and 28 in the vertical growth phase. RESULTS: ERK1/2 was widely expressed (100%) in all the (pigmented) lesions studied. p-ERK1/2 expression was much lower in compound (32.4%) and dysplastic (54.5%) naevi than in primary melanoma (nodular 78.8%, superficial spreading 67%) and subcutaneous metastases (76.3%). p-ERK expression was much lower in lymph node metastases (48.5%), suggesting that the microenvironment may influence the activation of ERK. There was a (non-significant) trend for p-ERK expression to be higher in thick (>1.0 mm) versus thin (< or =1.0 mm) melanoma (p = 0.23). There was a trend for overall survival to be related to p-ERK expression in patients with melanoma over 1 mm in thickness. CONCLUSIONS: Expression of activated ERK1/2 in melanocytic lesions appears to be related to malignant potential so that activation of ERK1/2 may be important in melanoma progression. These results provide important histological support for the proposal that inhibition of this signalling pathway may be useful in treatment of melanoma.
Mots-clé
Adolescent Adult Aged Aged, 80 and over Disease Progression Enzyme Activation Extracellular Signal-Regulated MAP Kinases/*metabolism Female Follow-Up Studies Humans Lymphatic Metastasis Male Melanoma/*enzymology/pathology/secondary Middle Aged Mitogen-Activated Protein Kinase 1/metabolism Mitogen-Activated Protein Kinase 3/metabolism Neoplasm Recurrence, Local/enzymology Nevus, Pigmented/enzymology Phosphorylation Signal Transduction Skin Neoplasms/*enzymology/pathology Survival Analysis Tumor Markers, Biological/*metabolism
Pubmed
Web of science
Création de la notice
25/01/2008 11:58
Dernière modification de la notice
03/03/2018 18:34
Données d'usage