Squamous Cell Cancers: A Unified Perspective on Biology and Genetics.

Détails

Ressource 1Télécharger: BIB_7AF7EBF5C40F.P001.pdf (1848.99 [Ko])
Etat: Public
Version: Author's accepted manuscript
ID Serval
serval:BIB_7AF7EBF5C40F
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Squamous Cell Cancers: A Unified Perspective on Biology and Genetics.
Périodique
Cancer cell
Auteur(s)
Dotto G.P., Rustgi A.K.
ISSN
1878-3686 (Electronic)
ISSN-L
1535-6108
Statut éditorial
Publié
Date de publication
09/04/2016
Peer-reviewed
Oui
Volume
29
Numéro
5
Pages
622-637
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
Squamous cell carcinomas (SCCs) represent the most frequent human solid tumors and are a major cause of cancer mortality. These highly heterogeneous tumors arise from closely interconnected epithelial cell populations with intrinsic self-renewal potential inversely related to the stratified differentiation program. SCCs can also originate from simple or pseudo-stratified epithelia through activation of quiescent cells and/or a switch in cell-fate determination. Here, we focus on specific determinants implicated in the development of SCCs by recent large-scale genomic, genetic, and epigenetic studies, and complementary functional analysis. The evidence indicates that SCCs from various body sites, while clinically treated as separate entities, have common determinants, pointing to a unified perspective of the disease and potential new avenues for prevention and treatment.

Mots-clé
Alcohol Drinking/adverse effects, Carcinoma, Squamous Cell/etiology, Carcinoma, Squamous Cell/genetics, Carcinoma, Squamous Cell/therapy, Gene Expression Regulation, Neoplastic, Genetic Predisposition to Disease/genetics, Humans, Infection/complications, Models, Genetic, Mutation, Smoking/adverse effects, Ultraviolet Rays/adverse effects
Pubmed
Open Access
Oui
Création de la notice
27/05/2016 8:52
Dernière modification de la notice
20/08/2019 14:36
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