Tubular Dysfunction in Idiopathic Nephrotic Syndrome

Details

Serval ID
serval:BIB_7ADBD5CD3C6B
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Institution
Title
Tubular Dysfunction in Idiopathic Nephrotic Syndrome
Title of the conference
15th Congress of the International Pediatric Nephrology Association
Author(s)
Girardin E., Ngoué Epée J., Chehade H., Parvex P.
Address
New York, United States, August 29-September 2, 2010
ISBN
0931-041X
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
25
Series
Pediatric Nephrology
Pages
1803
Language
english
Notes
Meeting Abstract
Abstract
Objectives:
To evaluate the degree of tubular involvement in INS at various stage of the disease.
Methods:
19 patients with INS were studied. 13 were steroid responders (group 1). 5 of them had biopsy which showed MCD. 6 patients were non responder to steroid or were steroid dependant with frequent relapses (group 2). Biopsies showed 3 FSGS and 3 MCD. They were treated with prednisone, ciclosporin and/ or mycofenolate mofetil. Protein, microalbumin (ALB), alpha-microglobulin (AMG), N-acetyl-beta-D-glucosaminidase (NAG) and creatinine (cr) were measured in each urine sample. Patients were considered in remission if prot/ cr ratio (g/mol) was < 20 (group 1a and 2a), and in relapse if the ratio was > 200 (group 1c and 2c). Some patients in group 1 had non nephrotic proteinuria (group 1b). Tubular dysfunction was defi ned by NAG/cr ratio (mg/mmol) > 0.86 or by AMG/cr ratio (mg/mmol) > 1.58.
Results:
Prot/cr ALB/cr NAG/cr AMG/cr
Group 1a 10.3 ± 4.1 1.1 ± 1.0 0.19 ± 0.12 1.40 ± 0.97
Group 1b 60.4 ± 63.4 42.8 ± 66.7 0.39 ± 0.21 1.20 ± 0.56
Group 1c 713.3 ± 276.8 799.8 ± 534.9 2.25 ± 1.86* 4.25 ± 2.09*
Group 2a 11.3 ± 6.1 4.7 ± 5.7 0.26 ± 0.19 1.18 ± 0.60
Group 2c 914.9 ± 718.6 682.9 ± 589.3 3.00 ± 2.72* 5.47 ± 4.30*
Results are mean ± SD, p < 0.001 compared to group 1a and 2a
No difference was observed between group 1 and group 2 neither in remission nor in relapse.
Conclusions:
These data indicate that tubular dysfunction occurs in INS but only in patients in relapse. In this population, tubular dysfunction was independent of the severity of the nephrotic syndrome, the treatment protocol and the histopathology.
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Create date
21/10/2010 11:52
Last modification date
20/08/2019 15:36
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