Article: article from journal or magazin.
Case report (case report): feedback on an observation with a short commentary.
Disposition of voriconazole during continuous veno-venous haemodiafiltration (CVVHDF) in a single patient.
The Journal of Antimicrobial Chemotherapy
Publication types: Case Reports ; Journal Article
OBJECTIVES: To determine whether voriconazole dosage adjustment is required during continuous veno-venous haemodiafiltration (CVVHDF). METHODS: Voriconazole pharmacokinetics were studied in a critically ill patient under CVVHDF. The analysis was carried out for 12 h following a 6 mg/kg dose. Voriconazole concentrations were measured by HPLC in blood inlet and outlet lines and in dialysate. RESULTS: The total body clearance of voriconazole was 20.3 L/h, with a terminal half-life of 13.7 h and a distribution volume of 399 L. The estimated sieving coefficient was 0.53 and the filtration-dialysis clearance 1.2 L/h. CONCLUSIONS: CVVHDF does not significantly affect voriconazole disposition and requires no dosage adjustment.
Aged, Antifungal Agents/blood, Antifungal Agents/pharmacokinetics, Area Under Curve, Chromatography, High Pressure Liquid, Fatal Outcome, Female, Half-Life, Hemofiltration, Humans, Kidney Failure, Chronic/metabolism, Kidney Failure, Chronic/therapy, Pneumonia, Pneumocystis/complications, Pneumonia, Pneumocystis/drug therapy, Pyrimidines/blood, Pyrimidines/pharmacokinetics, Respiratory Distress Syndrome, Adult/complications, Respiratory Distress Syndrome, Adult/drug therapy, Triazoles/blood, Triazoles/pharmacokinetics
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