Age and adverse drug reactions from psychopharmacological treatment: data from the AMSP drug surveillance programme in Switzerland.

Détails

Ressource 1Télécharger: BIB_7A2280A472CE.P001.pdf (937.72 [Ko])
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_7A2280A472CE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Age and adverse drug reactions from psychopharmacological treatment: data from the AMSP drug surveillance programme in Switzerland.
Périodique
Swiss Medical Weekly
Auteur(s)
Greil W., Häberle A., Schuhmann T., Grohmann R., Baumann Pierre
ISSN
1424-3997 (Electronic)
ISSN-L
0036-7672
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
143
Pages
w13772
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: epublish
Résumé
QUESTION UNDER STUDY: The frequency of severe adverse drug reactions (ADRs) from psychotropic drugs was investigated in hospitalised psychiatric patients in relation to their age. Specifically, the incidence of ADRs in patients up to 60 years was compared to that of patients older than 60 years.
METHODS: Prescription rates of psychotropic drugs and reports of severe ADRs were collected in psychiatric hospitals in Switzerland between 2001 and 2010. The data stem from the drug surveillance programme AMSP.
RESULTS: A total of 699 patients exhibited severe ADRs: 517 out of 28,282 patients up to 60 years (1.8%); 182 out of 11,446 elderly patients (1.6%, ns). Logistic regression analyses showed a significantly negative relationship between the incidence of ADRs and patients' age in general and in particular for weight gain, extrapyramidal motor system (EPMS) symptoms, increased liver enzymes and galactorrhoea. A significantly negative relationship was observed for age and the dosages of olanzapine, quetiapine, risperidone, valproic acid and lamotrigine. When comparing age groups, frequency of ADRs was lower in general for antipsychotic drugs and anticonvulsants, in particular for valproic acid in the elderly. Weight gain was found to be lower in the elderly for antipsychotic drugs, in particular for olanzapine. For the group of mood-stabilising anticonvulsants (carbamazepine, lamotrigine and valproic acid) the elderly exhibited a lower incidence of reported allergic skin reactions.
CONCLUSION: The results suggest that for psychiatric inpatients the incidence of common severe ADRs (e.g., weight gain or EPMS symptoms) arising from psychotropic medication decreases with the age of patients.
Mots-clé
Adolescent, Adult, Adverse Drug Reaction Reporting Systems, Age Factors, Aged, Aged, 80 and over, Antimanic Agents/adverse effects, Antipsychotic Agents/adverse effects, Basal Ganglia Diseases/chemically induced, Basal Ganglia Diseases/epidemiology, Benzodiazepines/adverse effects, Carbamazepine/adverse effects, Causality, Dibenzothiazepines/adverse effects, Drug-Related Side Effects and Adverse Reactions/epidemiology, Female, Galactorrhea/chemically induced, Galactorrhea/epidemiology, Humans, Logistic Models, Male, Middle Aged, Neuroleptic Malignant Syndrome/epidemiology, Risperidone/adverse effects, Severity of Illness Index, Switzerland/epidemiology, Triazines/adverse effects, Valproic Acid/adverse effects, Weight Gain, Young Adult
Pubmed
Web of science
Open Access
Oui
Création de la notice
31/08/2015 15:32
Dernière modification de la notice
08/05/2019 20:45
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