Differentiation of focal liver lesions: usefulness of parametric imaging with contrast-enhanced US.

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Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_7A0E763559A0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Differentiation of focal liver lesions: usefulness of parametric imaging with contrast-enhanced US.
Périodique
Radiology
Auteur(s)
Anaye Anass, Perrenoud Geneviève, Rognin Nicolas, Arditi Marcel, Mercier Laurent, Frinking Peter, Ruffieux Christiane, Peetrons Philippe, Meuli Reto, Meuwly Jean-Yves
ISSN
1527-1315 (Electronic)
ISSN-L
0033-8419
Statut éditorial
Publié
Date de publication
2011
Peer-reviewed
Oui
Volume
261
Numéro
1
Pages
300-310
Langue
anglais
Résumé
Purpose: To evaluate whether parametric imaging with contrast material-enhanced ultrasonography (US) is superior to visual assessment for the differential diagnosis of focal liver lesions (FLLs). Materials and Methods: This study had institutional review board approval, and verbal patient informed consent was obtained. Between August 2005 and October 2008, 146 FLLs in 145 patients (63 women, 82 men; mean age, 62.5 years; age range, 22-89 years) were imaged with real-time low-mechanical-index contrast-enhanced US after a bolus injection of 2.4 mL of a second-generation contrast agent. Clips showing contrast agent uptake kinetics (including arterial, portal, and late phases) were recorded and subsequently analyzed off-line with dedicated image processing software. Analysis of the dynamic vascular patterns (DVPs) of lesions with respect to adjacent parenchyma allowed mapping DVP signatures on a single parametric image. Cine loops of contrast-enhanced US and results from parametric imaging of DVP were assessed separately by three independent off-site readers who classified each lesion as benign, malignant, or indeterminate. Sensitivity, specificity, accuracy, and positive and negative predictive values were calculated for both techniques. Interobserver agreement (κ statistics) was determined. Results: Sensitivities for visual interpretation of cine loops for the three readers were 85.0%, 77.9%, and 87.6%, which improved significantly to 96.5%, 97.3%, and 96.5% for parametric imaging, respectively (P < .05, McNemar test), while retaining high specificity (90.9% for all three readers). Accuracy scores of parametric imaging were higher than those of conventional contrast-enhanced US for all three readers (P < .001, McNemar test). Interobserver agreement increased with DVP parametric imaging compared with conventional contrast-enhanced US (change of κ from 0.54 to 0.99). Conclusion: Parametric imaging of DVP improves diagnostic performance of contrast-enhanced US in the differentiation between malignant and benign FLLs; it also provides excellent interobserver agreement.
Pubmed
Web of science
Open Access
Oui
Création de la notice
02/08/2011 16:08
Dernière modification de la notice
08/05/2019 20:45
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