Immunogenetics of invasive aspergillosis.

Détails

ID Serval
serval:BIB_7A0766212047
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Immunogenetics of invasive aspergillosis.
Périodique
Medical Mycology
Auteur(s)
Lamoth F., Rubino I., Bochud P.Y.
ISSN
1460-2709 (Electronic)
ISSN-L
1369-3786
Statut éditorial
Publié
Date de publication
2011
Volume
49
Numéro
Suppl. 1
Pages
S125-S136
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
Invasive aspergillosis is one of the most important infections in hematopoietic stem cell transplant recipients, with an incidence rate of 5-15% and an associated mortality of 30-60%. It remains unclear why certain patients develop invasive aspergillosis while others, undergoing identical transplant regimen and similar post transplant immunosuppression, do not. Over the last decade, pattern recognition receptors such as Toll-like receptors (TLRs) and the C-type lectin receptors (CLRs) have emerged as critical components of the innate immune system. By detecting specific molecular patterns from invading microbes and initiating inflammatory and subsequent adaptive immune responses, pattern recognition receptors are strategically located at the molecular interface of hosts and pathogens. Polymorphisms in pattern recognition receptors and downstream signaling molecules have been associated with increased or decreased susceptibility to infections, suggesting that their detection may have an increasing impact on the treatment and prevention of infectious diseases in the coming years. Infectious risk stratification may be particularly relevant for patients with hematologic malignancies, because of the high prevalence and severity of infections in this population. This review summarizes the innate immune mechanisms involved in Aspergillus fumigatus detection and the role of host genetic polymorphisms in susceptibility to invasive aspergillosis.
Pubmed
Web of science
Création de la notice
21/01/2011 13:56
Dernière modification de la notice
03/03/2018 18:33
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