Immunogenetics of invasive aspergillosis.

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Version: Final published version
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It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_7A0766212047
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Immunogenetics of invasive aspergillosis.
Journal
Medical Mycology
Author(s)
Lamoth F., Rubino I., Bochud P.Y.
ISSN
1460-2709 (Electronic)
ISSN-L
1369-3786
Publication state
Published
Issued date
2011
Volume
49
Number
Suppl. 1
Pages
S125-S136
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
Invasive aspergillosis is one of the most important infections in hematopoietic stem cell transplant recipients, with an incidence rate of 5-15% and an associated mortality of 30-60%. It remains unclear why certain patients develop invasive aspergillosis while others, undergoing identical transplant regimen and similar post transplant immunosuppression, do not. Over the last decade, pattern recognition receptors such as Toll-like receptors (TLRs) and the C-type lectin receptors (CLRs) have emerged as critical components of the innate immune system. By detecting specific molecular patterns from invading microbes and initiating inflammatory and subsequent adaptive immune responses, pattern recognition receptors are strategically located at the molecular interface of hosts and pathogens. Polymorphisms in pattern recognition receptors and downstream signaling molecules have been associated with increased or decreased susceptibility to infections, suggesting that their detection may have an increasing impact on the treatment and prevention of infectious diseases in the coming years. Infectious risk stratification may be particularly relevant for patients with hematologic malignancies, because of the high prevalence and severity of infections in this population. This review summarizes the innate immune mechanisms involved in Aspergillus fumigatus detection and the role of host genetic polymorphisms in susceptibility to invasive aspergillosis.
Pubmed
Web of science
Open Access
Yes
Create date
21/01/2011 12:56
Last modification date
21/11/2022 8:15
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