Partly Fermented Infant Formulae With Specific Oligosaccharides Support Adequate Infant Growth and Are Well-Tolerated.

Détails

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Etat: Serval
Version: Final published version
ID Serval
serval:BIB_7A0165956B8F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Partly Fermented Infant Formulae With Specific Oligosaccharides Support Adequate Infant Growth and Are Well-Tolerated.
Périodique
Journal of pediatric gastroenterology and nutrition
Auteur(s)
Huet F., Abrahamse-Berkeveld M., Tims S., Simeoni U., Beley G., Savagner C., Vandenplas Y., Hourihane J.O.
ISSN
1536-4801 (Electronic)
ISSN-L
0277-2116
Statut éditorial
Publié
Date de publication
10/2016
Peer-reviewed
Oui
Volume
63
Numéro
4
Pages
e43-53
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Multicenter Study ; Randomized Controlled Trial
Publication Status: ppublish
Résumé
Fermented formulae (FERM) and a specific mixture of 90% short-chain galacto-oligosaccharides and 10% long-chain fructo-oligosaccharides (scGOS/lcFOS; 9:1) have a potential beneficial effect on gastrointestinal function and microbiota development in infants. The present study assessed the safety and tolerance of the combination of partly fermented infant milk formulae and scGOS/lcFOS compared with either 1 feature, in healthy term infants.
Four hundred thirty-two infants were enrolled before 28 days of age and followed up to 17 weeks of age and assigned to 1 of the 4 groups: (i) formula with scGOS/lcFOS, (ii) scGOS/lcFOS + 15% FERM, (iii) scGOS/lcFOS + 50% FERM, or (iv) 50% fermented formula (50% FERM). Primary outcome was daily weight gain during intervention (equivalence criterion: difference in daily weight gain ≤3 g/day). Infants' anthropometrics, formula intake, number, and type of (serious) AEs were monitored monthly. Stool samples were collected at baseline and after 17 weeks for analysis of physiological and microbiological parameters.
Equivalence of weight gain per day was demonstrated in both the intention-to-treat and per-protocol population, with a mean weight gain (SD) of 29.7 (6.1), 28.2 (4.8), 28.5 (5.0), and 28.7 (5.9) g/day for the groups i to iv respectively. No differences were observed in other growth parameters, formula intake, and the number or severity of AEs. In all scGOS/lcFOS-containing formulae, a beneficial effect of scGOS/lcFOS was observed, indicated by the lower pH, lower Clostridium difficile levels, and higher secretory immunoglobulin A levels.
The partly fermented infant milk formulae containing the specific mixture scGOS/lcFOS were well-tolerated and resulted in normal growth in healthy infants.

Mots-clé
Clostridium difficile/isolation & purification, Double-Blind Method, Feces/microbiology, Female, Follow-Up Studies, Humans, Infant, Infant Formula/adverse effects, Infant, Newborn, Male, Oligosaccharides/adverse effects, Outcome Assessment (Health Care), Prospective Studies, Weight Gain
Pubmed
Web of science
Création de la notice
07/10/2016 16:54
Dernière modification de la notice
03/03/2018 18:33
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