Prognostic criteria in nonfunctioning pancreatic endocrine tumours.

Détails

ID Serval
serval:BIB_79FEBFFB59D2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Prognostic criteria in nonfunctioning pancreatic endocrine tumours.
Périodique
Virchows Archiv : An International Journal of Pathology
Auteur(s)
La Rosa S., Sessa F., Capella C., Riva C., Leone B.E., Klersy C., Rindi G., Solcia E.
ISSN
0945-6317 (Print)
ISSN-L
0945-6317
Statut éditorial
Publié
Date de publication
1996
Peer-reviewed
Oui
Volume
429
Numéro
6
Pages
323-333
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
To identify prognostic subgroups among non-functioning (nonsyndromic) pancreatic endocrine tumours, a series of 61 tumours were analysed systematically for macroscopic, histopathological and immunohistochemical variables potentially predictive of malignancy. High-grade nuclear atypia, elevated mitotic rate and multifocal necrosis allowed us to separate 5 poorly differentiated carcinomas from 56 well differentiated tumours. Among the latter, 29 well-differentiated carcinomas showing gross local invasion or metastases were identified. Vascular or perineural microinvasion, Ki67 proliferative index > 2%, mitotic rate > or = 2, size > or = 4 cm, capsular penetration, nuclear atypia, lack of progesterone receptors and presence of calcitonin were among the variables correlated with malignancy. The first two were the most sensitive and specific. Their presence or absence was used in the 27 tumours lacking evidence of malignancy at the time of surgery to separate 11 cases with increased risk of malignancy (in 2 of which metastases developed during follow-up) from 16 cases with limited risk. The resulting four prognostic groups of non-functioning pancreatic endocrine tumours (limited- and increased-risk tumours, well-differentiated carcinomas and poorly differentiated carcinomas) showed distinct survival curves, which were significantly affected by vascular microinvasion, Ki67 proliferative index and metastases.
Mots-clé
Adult, Aged, Carcinoma/metabolism, Carcinoma/pathology, Endocrine Gland Neoplasms/metabolism, Endocrine Gland Neoplasms/pathology, Female, Humans, Immunohistochemistry, Ki-67 Antigen/analysis, Male, Middle Aged, Mitosis, Necrosis, Neoplasm Invasiveness, Pancreatic Neoplasms/metabolism, Pancreatic Neoplasms/pathology, Prognosis, Risk Factors, Survival Analysis
Pubmed
Web of science
Création de la notice
07/09/2016 9:42
Dernière modification de la notice
03/03/2018 18:33
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