Effect of endotoxin on the hypothalamic-pituitary-adrenal axis in sheep

Détails

ID Serval
serval:BIB_79FD88D5F783
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Effect of endotoxin on the hypothalamic-pituitary-adrenal axis in sheep
Périodique
European Journal of Endocrinology
Auteur(s)
Dadoun  F., Guillaume  V., Sauze  N., Farisse  J., Velut  J. G., Orsoni  J. C., Gaillard  R., Oliver  C.
ISSN
0804-4643 (Print)
Statut éditorial
Publié
Date de publication
02/1998
Volume
138
Numéro
2
Pages
193-7
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Feb
Résumé
Endotoxin has been shown to stimulate ACTH and cortisol secretion through an action at the hypothalamic level. However, the nature of hypothalamic neurohormones, corticotropin-releasing hormone (CRH) and especially arginine vasopressin (AVP), involved in that regulation is still controversial. The purpose of this study was to determine the effects of an acute i.v. endotoxin administration on CRH and AVP secretion into hypophysial portal blood (HPB). The experiment has been performed in sheep since it is possible to collect HPB and quantify CRH and AVP secretion in this animal under physiological conditions. The release of both peptides into HPB was stimulated by endotoxin injection, the increase in portal AVP being more pronounced than that of CRH. An initial, transient, increase in jugular AVP concentrations was observed, probably due to the activation of magnocellular AVP neurons. In conclusion, our data indicate that the activation of the pituitary-adrenal axis after endotoxin injection is associated with an increased release of both CRH and AVP into HPB. Magnocellular AVP neurons are initially stimulated while parvocellular CRH and AVP neurons are stimulated throughout the experiment.
Mots-clé
Adrenocorticotropic Hormone/blood Animals Arginine Vasopressin/blood/*secretion Corticotropin-Releasing Hormone/blood/*secretion Hydrocortisone/blood Hypothalamo-Hypophyseal System/*drug effects Lipopolysaccharides/*pharmacology Pituitary-Adrenal System/*drug effects Sheep
Pubmed
Web of science
Création de la notice
15/02/2008 17:57
Dernière modification de la notice
03/03/2018 18:33
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