Sodium balance and hypertension: rare genetic disorders expose pathogenic mechanisms

Détails

ID Serval
serval:BIB_79EBB3C5097F
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Sodium balance and hypertension: rare genetic disorders expose pathogenic mechanisms
Périodique
Experimental Nephrology
Auteur(s)
Burnier  M.
ISSN
1018-7782 (Print)
Statut éditorial
Publié
Date de publication
12/1998
Volume
6
Numéro
6
Pages
496-501
Notes
Journal Article
Review --- Old month value: Nov-Dec
Résumé
The importance of sodium in the pathophysiology of hypertension has been revealed by several sources, including large epidemiological analyses, interventional trials, and a large body of experimental and clinical evidence. According to Guyton's hypothesis, a shift of the pressure-natriuresis curve has been described in all forms of hypertension, suggesting that the ability of the kidney to excrete sodium must be altered in hypertension. Yet, the intrarenal mechanism responsible for the abnormal salt excretion remains unknown. In recent years, the discovery of the molecular mechanisms involved in the pathogenesis of some rare forms of hypertension, i.e. , Liddle's syndrome, glucocorticoid-remediable hypertension, and apparent mineralocorticoid excess, has revived the interest in salt-induced hypertension, since the reported genetic defects decrease the ability of the kidneys to excrete sodium. This review presents the pathogenic mechanisms revealed by these rare disorders and discusses the possible implication of these discoveries for the understanding of the pathophysiology of essential hypertension.
Mots-clé
Animals Genes, Dominant/physiology Glucocorticoids/therapeutic use Humans Hyperaldosteronism/drug therapy/genetics/physiopathology Hypertension/genetics/*metabolism/physiopathology Kidney/physiopathology Mineralocorticoids/blood Natriuresis/physiology Sodium/*metabolism
Pubmed
Web of science
Création de la notice
25/01/2008 13:55
Dernière modification de la notice
03/03/2018 18:32
Données d'usage