The Fragile X mental retardation protein regulates matrix metalloproteinase 9 mRNA at synapses.

Détails

ID Serval
serval:BIB_79E7C1DFDEF3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The Fragile X mental retardation protein regulates matrix metalloproteinase 9 mRNA at synapses.
Périodique
The Journal of neuroscience : the official journal of the Society for Neuroscience
Auteur(s)
Janusz A., Milek J., Perycz M., Pacini L., Bagni C., Kaczmarek L., Dziembowska M.
ISSN
1529-2401 (Electronic)
ISSN-L
0270-6474
Statut éditorial
Publié
Date de publication
13/11/2013
Volume
33
Numéro
46
Pages
18234-18241
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Activity-dependent protein synthesis at synapses is dysregulated in the Fragile X syndrome (FXS). This process contributes to dendritic spine dysmorphogenesis and synaptic dysfunction in FXS. Matrix Metalloproteinase 9 (MMP-9) is an enzyme involved in activity-dependent reorganization of dendritic spine architecture and was shown to regulate spine morphology in a mouse model of FXS, the Fmr1 knock-out mice. Here we show that MMP-9 mRNA is part of the FMRP complex and colocalizes in dendrites. In the absence of FMRP MMP-9 mRNA translation is increased at synapses, suggesting that this mechanism contributes to the increased metalloproteinase level at synapses of Fmr1 knock-out mice. We propose that such a local effect can contribute to the aberrant dendritic spine morphology observed in the Fmr1 knock-out mice and in patients with FXS.

Mots-clé
Animals, Dendrites/enzymology, Dendrites/genetics, Female, Fragile X Mental Retardation Protein/physiology, Hippocampus/enzymology, Matrix Metalloproteinase 9/biosynthesis, Matrix Metalloproteinase 9/genetics, Mice, Mice, Knockout, RNA, Messenger/biosynthesis, RNA, Messenger/genetics, Rats, Synapses/enzymology, Synapses/genetics
Pubmed
Open Access
Oui
Création de la notice
06/03/2017 18:23
Dernière modification de la notice
08/05/2019 20:44
Données d'usage