Clinical characteristics, audiological and neurodevelopmental outcomes of newborns with congenital cytomegalovirus infection.

Détails

ID Serval
serval:BIB_79D939CFAC13
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Clinical characteristics, audiological and neurodevelopmental outcomes of newborns with congenital cytomegalovirus infection.
Périodique
Swiss medical weekly
Auteur(s)
Kobas M., Bickle Graz M., Truttmann A.C., Giannoni E., Meylan P., Asner S.A.
ISSN
1424-3997 (Electronic)
ISSN-L
0036-7672
Statut éditorial
Publié
Date de publication
2018
Peer-reviewed
Oui
Volume
148
Pages
w14627
Langue
anglais
Notes
Publication types: Journal Article ; Observational Study
Publication Status: epublish
Résumé
Congenital cytomegalovirus (cCMV) infections are the leading nongenetic cause of congenital sensorineural hearing loss (SNHL); however the true impact of cCMV infections remains unknown.
(1) To identify the number of asymptomatic and symptomatic cCMV infections diagnosed between 1999 and 2014 at the Lausanne University Hospital; (2) to describe the audiological and neurodevelopmental outcomes of infants with cCMV infection; and (3) to compare clinical outcomes between infants born to mothers with primary versus nonprimary infection.
This was a single-centre, observational, exploratory, retrospective study of newborns diagnosed with cCMV infection at the Lausanne University Hospital between 1999 and 2014.
Fifty newborns with cCMV infection were identified; 39 (78%) were symptomatic at birth, of whom 29 (74%) were neurologically symptomatic. Twelve children (24%) presented with subsequent abnormal audiological and/or neurodevelopmental outcomes. Newborns born to mothers with a nonprimary infection were more often symptomatic at birth than those born to mothers with a primary infection.
All infants with subsequent SNHL or abnormal neurodevelopment were symptomatic at birth. Similar long-term neurodevelopmental and audiological outcomes were observed in infants born to mothers with a primary and nonprimary infection.
Mots-clé
Cytomegalovirus Infections/congenital, Cytomegalovirus Infections/diagnosis, Cytomegalovirus Infections/epidemiology, Female, Hearing Loss, Sensorineural/congenital, Hearing Loss, Sensorineural/diagnosis, Hearing Tests/methods, Humans, Infant, Infant, Newborn, Male, Maternal Exposure, Mothers, Neonatal Screening/methods, Retrospective Studies, Switzerland/epidemiology
Pubmed
Web of science
Création de la notice
25/06/2018 10:08
Dernière modification de la notice
13/11/2018 7:26
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