Hepatobiliary scintigraphy allows the evaluation of short-term functional toxicity of liver stereotactic body radiotherapy: Results of a pilot study.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_79CF07459545
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Hepatobiliary scintigraphy allows the evaluation of short-term functional toxicity of liver stereotactic body radiotherapy: Results of a pilot study.
Périodique
PloS one
Auteur(s)
De Bari B., Breuneval T., Zeverino M., Godin S., Deantonio L., Geldhof C., Bourhis J., Schaefer N., Moeckli R., Prior J., Ozsahin M.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Statut éditorial
Publié
Date de publication
2018
Peer-reviewed
Oui
Volume
13
Numéro
10
Pages
e0204013
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
To study the potential of (99m)Tc-Mebrofenin hepatobiliary scintigraphy (HBS) in identifying the short-term variations of liver function after stereotactic body radiotherapy (SBRT) for liver cancers.
We treated with SBRT 3 patients (pts) affected by a cholangiocarcinoma and 3 patient presenting liver metastases (3x15 Gy, 4 pts; 5x8 Gy, 1 pt; 6x5 Gy, 1 pt). All patients received HBS before and 3 months after SBRT, which were co-registered with the simulation CT-scan. Structures corresponding to isodoses from 10-90 Gy were created, with intervals of 10 Gy. Finally, the variations of the mean activity (MBq) in each isodose structure have been calculated. Then, a linear regression analysis was performed.
We showed a linear reduction of the activity, significantly related to the delivered dose (p<0.01), and a reduction of the perfusion of 0.78% for each delivered Gy. The linear equation has predictive value of the loss of the function of 96% (R2 = 0.9605).
HBS could improve treatment plans for liver SBRT, by allowing the identification of the liver function variations after SBRT and, potentially, the prediction of remnant liver function after SBRT. These preliminary results should be confirmed on long-term prospective data and larger population.
Mots-clé
Aged, Aged, 80 and over, Bile Duct Neoplasms/radiotherapy, Cholangiocarcinoma/radiotherapy, Dose Fractionation, Radiation, Female, Humans, Imino Acids/administration & dosage, Linear Models, Liver Function Tests, Liver Neoplasms/diagnostic imaging, Liver Neoplasms/physiopathology, Liver Neoplasms/radiotherapy, Liver Neoplasms/secondary, Male, Middle Aged, Organotechnetium Compounds/administration & dosage, Pilot Projects, Prospective Studies, Radionuclide Imaging/methods, Radiosurgery/adverse effects, Tomography, X-Ray Computed, Treatment Outcome
Pubmed
Web of science
Open Access
Oui
Création de la notice
17/10/2018 10:22
Dernière modification de la notice
28/08/2019 16:38
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