Fat oxidation and adiposity in prepubertal children: exogenous versus endogenous fat utilization.

Détails

ID Serval
serval:BIB_7976904CB981
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Fat oxidation and adiposity in prepubertal children: exogenous versus endogenous fat utilization.
Périodique
Journal of Clinical Endocrinology and Metabolism
Auteur(s)
Maffeis C., Armellini F., Tatò L., Schutz Y.
ISSN
0021-972X (Print)
ISSN-L
0021-972X
Statut éditorial
Publié
Date de publication
02/1999
Volume
84
Numéro
2
Pages
654-658
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Fat balance plays an important role in fat mass regulation. The mechanisms by which fat intake and fat oxidation are controlled are poorly understood. In particular, no data are available on the origin, i.e. exogenous (meal intake) or endogenous (adipose tissue lipolysis), of fat oxidized during the postprandial period in children and the proportion between these two components. In this study we tested the hypothesis that there is a relationship between adiposity and the oxidative fate of fat taken with a mixed meal in a group of 15 children with a wide range of fat mass (9-64%). The combination of stable isotope analysis ([13C] enriched fatty acids added to a mixed meal) and indirect calorimetry allowed us to differentiate between the exogenous and endogenous resting fat oxidation rate over the 9-h postprandial period. During the 9 hours of the postprandial period, the children oxidized an amount of fat comparable to that ingested with the meal [26.8 (+/-2.31) g vs. 26.4 (+/-2.3) g, respectively, P = ns]. On average, exogenous fat oxidation [2.99 (+/-3.0) g/9 h] represented 10.8% (+/-0.9) of total fat oxidation. Endogenous fat oxidation, calculated as the difference between total fat oxidation and exogenous fat oxidation, averaged 23.4 (+/-1.9) g/9 h and represented 88.2% (+/-0.9) of total fat oxidation. Endogenous fat oxidation as well as exogenous fat oxidation were highly correlated to total fat oxidation (r = 0.83, P < 0.001; r = 0.84, P < 0.001, respectively). Exogenous fat oxidation expressed as a proportion of total fat oxidation was directly related to fat mass (r = 0.56, P < 0.03), while endogenous fat oxidation expressed as a proportion of total fat oxidation was inversely related (r = -0.57, P < 0.03) to the degree of adiposity. The enhanced exogenous fat oxidation observed when adiposity increases in the dynamic phase of obesity may be viewed as a protective mechanism to prevent further increase in fat mass and hence to maintain fat oxidation at a sufficient rate when the body is exposed to a high amount of dietary fat, as typically encountered in obese children.
Mots-clé
Adipose Tissue/metabolism, Body Composition, Breath Tests, Carbon Dioxide/analysis, Carbon Isotopes, Child, Dietary Fats/administration & dosage, Dietary Fats/metabolism, Energy Metabolism, Fatty Acids/administration & dosage, Female, Food, Humans, Kinetics, Lipid Metabolism, Lipolysis, Male, Obesity/metabolism, Oxidation-Reduction
Pubmed
Web of science
Open Access
Oui
Création de la notice
21/01/2008 14:09
Dernière modification de la notice
08/05/2019 20:43
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